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pro vyhledávání: '"556"'
Autor:
Elizabeth E. Hull, Brianna Flores
Publikováno v:
Cancer Research. 78:556-556
The tumor suppressor p53 protein is mutated in over 50% of cancers. The most frequent mutations in p53, termed “hotspot” mutations, occur in the DNA binding domain of the p53 protein. These mutations not only remove normal p53 function but also c
Autor:
Gabriele Matschiner, Corinna Schlosser, Sven Berger, Marlon Hinner, Ulrich Moebius, Christine Rothe, Alexander Wiedenmann, Andrea Allersdorfer, Rachida-Siham Bel Aiba, Shane Olwill
Publikováno v:
Cancer Research. 76:556-556
Background. CD137 (4-1BB) is a key costimulatory immunoreceptor and a member of the TNF-receptor (TNFR) superfamily. While multiple lines of evidence show that CD137 is a highly promising therapeutic target in cancer, current mAb-based approaches are
Autor:
Kentaro Kishi, Yasuo Urata, Masaki Mori, Kenta Furukawa, Toshimitsu Irei, Masaki Wakasugi, Masashi Inoue, Shinya Yamashita, Yuichiro Doki, Masahiro Tanemura, Hiroaki Nagano, Nobuyoshi Hatanaka, Hiroki Akamatsu
Publikováno v:
Cancer Research. 75:556-556
Circulating tumor cells (CTCs) are thought to be “metastatic intermediates”. Recently, we reported encouraging survival rates following neoadjuvant therapy using gemcitabine (Gem) and S-1 concurrently with radiotherapy (NACRT) in patients (pts) w
Autor:
Tvrtko Hudolin, Giulio C. Spagnoli, Maurizio Provenzano, Lukas Bubendorf, Chantal Mengus, Tullio Sulser, Giovanni Sais, Stephen Wyler, Irina Banzola, Hans H. Hirsch
Publikováno v:
Cancer Research. 72:556-556
Background: Polyomavirus BK (BKV) large tumor antigen (L-Tag) contributes to oncogenesis by regulating crucial pathways of human cell cycle when non-permissive cells are infected. Therefore, L-Tag has been identified as an important target of immune
Autor:
Trey Ideker, Danielle L. Swaney, Keiichiro Ono, Nevan J. Krogan, Erica Silva, Julia Shangguan, Fan Zheng, Minkyu Kim, Dexter Pratt, Xiaolin Nan
Publikováno v:
Cancer Research. 80:PR14-PR14
Interpreting cancer genomes requires a broad understanding of the composition and organization of cellular processes under selective pressure for mutations. Here, we integrate systematic screens for protein interaction with tumor genetic analysis to
Autor:
Suzanne A. Eccles, Faith E. Davis, Gerhardt Attard, Gary Box, Simon P. Robinson, Johann S. de Bono, Timothy J. Graham
Publikováno v:
Cancer Research. 73:3924-3924
Prostate cancer (PCa) growth is incurable once it has metastasized to the bone microenvironment (BM). The altered BM provides a permissive niche to support tumour growth, and therapeutic strategies that target tumour-bone interactions and/or restore