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pro vyhledávání: ''
Autor:
Yukyung Jun, Yun-Suhk Suh, SungHee Park, Jieun Lee, Jong-Il Kim, Sanghyuk Lee, Wan-Ping Lee, Olga Anczuków, Han-Kwang Yang, Charles Lee
Publikováno v:
Cancer Research. 82:543-555
Alternatively spliced RNA isoforms are a hallmark of tumors, but their nature, prevalence, and clinical implications in gastric cancer have not been comprehensively characterized. We systematically profiled the splicing landscape of 83 gastric tumors
Autor:
Qinghua Han, Lindsey A. Barner, Lawrence D. True, Chenyi Mao, Andrew Janowczyk, Pingfu Fu, Robert Serafin, Nicholas P. Reder, Anant Madabhushi, Jonathan T. C. Liu, Can Fahrettin Koyuncu, Patrick Leo, Sarah Hawley, Weisi Xie, Hongyi Huang, Jonathan L. Wright, Gan Gao, Adam K. Glaser, Soyoung Kang, Kevin Bishop, Nadia Postupna, C. Dirk Keene, Joshua C. Vaughan
Publikováno v:
Cancer Res
Prostate cancer treatment planning is largely dependent upon examination of core-needle biopsies. The microscopic architecture of the prostate glands forms the basis for prognostic grading by pathologists. Interpretation of these convoluted three-dim
Autor:
Xiangjun Xiao, James McKay, Yanhong Liu, David C. Christiani, Rayjean J. Hung, Chao Cheng, Wei Hong, John K. Field, Ang Li, Christopher I. Amos
Publikováno v:
Cancer Res
Clonal hematopoiesis (CH) is a phenomenon caused by expansion of white blood cells descended from a single hematopoietic stem cell. While CH can be associated with leukemia and some solid tumors, the relationship between CH and lung cancer remains la
Autor:
Kimia Sobhani, Jennifer E. Van Eyk, James L. Stewart, Warren G. Tourtellotte, Justin Darrah, Joslyn Foley, Wendy Cozen, Karen L. Reckamp, Susan Cheng, Alain C. Mita, So Yung Choi, Carissa A. Huynh, Noah Merin, Sandy Joung, Tucker Lemos, Robert Vescio, Ronald Paquette, Dermot P.B. McGovern, Edwin C. Frias, John Prostko, Omid Hamid, Joseph E. Ebinger, Emebet Mengesha, Reva Basho, Greg Botwin, Jun Gong, Nathalie Nguyen, Jonathan Braun, Inderjit Mehmi, Jane C. Figueiredo, Akil Merchant, Gil Y. Melmed, Laurel J Finster
Publikováno v:
Cancer Res
Longitudinal studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced immune responses in patients with cancer are needed to optimize clinical care. In a prospective cohort study of 366 (291 vaccinated) patients, we mea
Autor:
Shun-Qing Liang, Haibin Deng, Ren-Wang Peng, Gregor J. Kocher, Sabina Berezowska, Qinghua Zhou, Zhang Yang, Rémy Bruggmann, Sean Hall, Yanyun Gao, Duo Xu, Thomas M. Marti, Ralph A. Schmid, Haitang Yang
Publikováno v:
Cancer research, vol. 81, no. 11, pp. 3121-3133
Oncogenic activation of the FGFR pathway is frequent in lung and other cancers. However, due to drug resistance, pharmacological blockage of aberrant FGFR signaling has provided little clinical benefit in patients with FGFR-amplified tumors. The dete
Association between Smoking History and Tumor Mutation Burden in Advanced Non–Small Cell Lung Cancer
Autor:
Mark M. Awad, David C. Christiani, Xihao Li, Tom C. Nguyen, Xihong Lin, Xinan Wang, Bruce E. Johnson, Biagio Ricciuti, Michael S. Rabin
Publikováno v:
Cancer Res
Lung carcinogenesis is a complex and stepwise process involving accumulation of genetic mutations in signaling and oncogenic pathways via interactions with environmental factors and host susceptibility. Tobacco exposure is the leading cause of lung c
Publikováno v:
Cancer Res
The sum of target lesions is routinely used to evaluate patient objective responses to treatment in the RECIST criteria, but it fails to address response heterogeneity across metastases. This study argues that spatiotemporal heterogeneity across meta
Autor:
Takeshi Irie, Joshua S. Mincer, Roy Mano, Joseph R. Scarpa, Gregory W. Fischer, Fengshen Kuo, A. Ari Hakimi, Renzo G. DiNatale, Patrick J. McCormick, Andrew W. Silagy
Publikováno v:
Cancer Res
While opioids constitute the major component of perioperative analgesic regimens for surgery in general, a variety of evidence points to an association between perioperative opioid exposure and longer term oncologic outcomes. The mechanistic details
Publikováno v:
Cancer Res
Circadian disruption may play a role in carcinogenesis. Recent research suggests that light at night (LAN), a circadian disruptor, may be a risk factor for cancer. Moreover, LAN has been linked to obesity and diabetes, two risk factors for pancreatic
Publikováno v:
Cancer Research. 81:344-355
Circular RNAs (circRNA) are a new member of endogenously produced noncoding RNAs that have been characterized as key regulators of gene expression in a variety of malignances. However, the role of circRNA in oral squamous cell carcinoma (OSCC) remain