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Publikováno v:
Cancer Medicine
Patients with nonresectable metastatic neuroendocrine tumors (NETs) experience symptoms of hormone hypersecretion including diarrhea, flushing, and bronchoconstriction, which can interfere with quality of life [Anthony and Vinik (2011) Pancreas, 40:9
Autor:
Chihaya Hinohara, Teruki Hagiwara, Yuki I. Kawamura, Oki Miyake, Toshio Shimizu, Miwa Tamura-Nakano, Takuhito Sezaki, Takeshi Otsubo, Taeko Dohi, Kazuhiko Yamada
Publikováno v:
Cancer Medicine
Periplakin (PPL), a member of the plakin family of proteins that localizes to desmosomes and intermediate filaments, is downregulated in human esophageal squamous cell carcinoma (ESCC). Little is known, however, about the molecular mechanism underlyi
Autor:
Mari Nishio, Nobuhisa Takase, Soken Utsunomiya, Hiroshi Yokozaki, Naoki Urakawa, Takahide Komori, Yu-ichiro Koma, Yoshihiro Kakeji, Hiroaki Akiyama, Manabu Shigeoka
Publikováno v:
Cancer Medicine
Tumor-associated macrophages (TAMs) are known to be involved in the progression of various human malignancies. We previously demonstrated that CD204 was a useful marker for TAMs contributing to the angiogenesis, progression, and prognosis of human es
Publikováno v:
Cancer Medicine
Somatic mutations in cancer cell genes are classified according to their functional significance. Those that provide the malignant cells with significant advantage are collectively referred to as driver mutations and those that do not, are the passen
Autor:
Noora Andersson, Ralf Bützow, Anniina Färkkilä, Mikko Anttonen, Arto Leminen, Markku Heikinheimo, Leila Unkila-Kallio
Publikováno v:
Cancer Medicine
Granulosa cell tumors (GCTs) carry a risk of recurrence also at an early stage, but reliable prognostic factors are lacking. We assessed clinicopathological prognostic factors and the prognostic roles of the human epidermal growth factor receptors (H
Autor:
Charles P. Theuer, Bonne J. Adams, Nam Y. Lee, Herbert Hurwitz, Andrew Dellinger, Andrew B. Nixon, Yingmiao Liu, John C. Brady, Mark D. Starr, Herbert Pang
Publikováno v:
Cancer Medicine
TRC105 is an endoglin-targeting drug that possesses anti-angiogenic and antitumor potential. Analysis of the initial phase I trial of TRC105 demonstrated good tolerability and efficacy in cancer patients. In this report, we analyzed multiple circulat
Autor:
Gerard C. Blobe, Haiyan Li, Herbert Pang, Hope E. Uronis, Mark D. Starr, Michael A. Morse, Kellen L. Meadows, Andrew B. Nixon, Jon P. Gockerman, Herbert Hurwitz, Stephanie M. Cushman, Johanna C. Bendell, Andrew Dellinger
Publikováno v:
Cancer Medicine
Targeting multiple regulators of tumor angiogenesis have the potential to improve treatment efficacy. Bevacizumab is a monoclonal antibody directed against vascular endothelial growth factor and ABT-510 is a synthetic analog of thrombospondin, an end
Autor:
Masahiko Maekawa, Motoki Yano, Katsuhiro Okuda, Yoshitaka Fujii, Satoru Moriyama, Masayuki Shitara, Hidefumi Sasaki, Shigeki Shimizu, Yu Hikosaka, Yoichi Tani, Keisuke Yokota
Publikováno v:
Cancer Medicine
RET encodes the tyrosine kinase receptor of growth factors belonging to the glial-derived neurotrophic factor family. Recently, RET gene rearrangements with N-terminal of KIF5B gene were identified in lung adenocarcinomas from large-scale sequencing.