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Autor:
Sarah Gandarillas, Valérie Choesmel-Cadamuro, Nathalie Van Acker, Camille Franchet, Y Barreira, Christele Segura, Loïc Van Den Berghe, Carine Froment, Klaus M. Hahn, Jiaying Liu, Odile Burlet-Schiltz, Andrei V. Karginov, Xiaobo Wang, Georges Czaplicki, Karine Belguise, Florence Dalenc, Lucie Chadelle
Publikováno v:
Cancer Lett
The cytoskeleton and cell-matrix adhesions constitute a dynamic network that controls cellular behavior during development and cancer. The Focal Adhesion Kinase (FAK) is a central actor of these cell dynamics, promoting cell-matrix adhesion turnover
Publikováno v:
Cancer Letters. 526:91-102
Cancer cells display metabolic alterations to meet the bioenergetic demands for their high proliferation rates. Succinate is a central metabolite of the tricarboxylic acid (TCA) cycle, but was also shown to act as an oncometabolite and to specificall
Autor:
Xiaomin Ma, Yueke Lin, Lihui Zhu, Yeping Cheng, Weiqiang Jing, Xuecheng Shen, Lihui Han, Tao Li, Caiyu Sun, Xiaoting Lv, Dapeng Ma, Min Yang, Yunxue Zhao, Zhenzhi Qin, Gaozhong Xiong, Haocheng Xuan
Publikováno v:
Cancer Letters. 526:180-192
Hepatocellular carcinoma (HCC), a heterogeneous cancer with high mortality, is resistant to single targeted therapy; thus, combination therapy based on synthetic lethality is a promising therapeutic strategy for HCC. Poly (adenosine diphosphate [ADP]
Autor:
Sanjiv Kumar Yadav, Jayshree L. Hirpara, Shazib Pervaiz, Soo Fern Lee, Karishma Sashaphibulkij, Jianhua Qu
Publikováno v:
Cancer Letters. 526:284-303
We report a novel topoisomerase IIα inhibitor, mercaptopyridine oxide (MPO), which induces G2/M arrest and senescence with distinctly different cell cycle regulators (p21 or p14ARF) in HCT116p 53WT and HCT116 p53−/− cells, respectively. MPO trea
Autor:
Zhinan Yin, Nan-Xi Shi, Ying Xie, Chuangyu Wen, Guangqiang Li, Xuejia Lin, Zhi-Yong Li, Weicai Huang, Xiaobin Wu, Leqing Zhu, Mingxia Deng, Yuanyuan Duan
Publikováno v:
Cancer Letters. 526:322-334
The relationship between microRNA (miRNA) and hosting long non-coding RNA (lncRNA) remains unclear. Here, the expression levels of microRNA-210 (miR-210) and hosting lncRNA MIR210HG are significantly increased and positively correlated in gastric can
Publikováno v:
Cancer Letters. 526:193-204
Low in dietary ω3 polyunsaturated fatty acid (PUFA) consumption has been associated with increased incidence of cancers. Many basic and clinical studies have been conducted over the last several decades. We previously reviewed multi-targeted therapy
Autor:
Jialin Wang, Wei Xue, Xinxing Du, Huixiang Xiao, Baijun Dong, Nan Jing, Xiao Wang, Yu-Xiang Fang, Wei-Qiang Gao
Publikováno v:
Cancer Letters. 526:76-90
Most prostate cancer (PCa)-related deaths are caused by progression to bone metastasis. Recently, the importance of extracellular vesicles (EVs) in pre-metastatic niche formation has been reported. However, whether and how tumor-derived EVs interact
Publikováno v:
Cancer Letters. 526:168-179
Bladder cancers, and specifically urothelial carcinoma, have few effective treatment options, and tumors typically develop resistance against standard of care chemotherapies leading to significant mortality. The development of alternative therapies w
Publikováno v:
Cancer Letters. 524:109-120
Prostate cancer (PCa), especially castration-resistant PCa, is a common and fatal disease. circRNAs had been confirmed to affect the proliferation of a variety of malignant tumors. Exploring the role of circRNAs in PCa progression and discovering new
Autor:
Guillermo Calero, Sandra Vergara, Cynthia Adams, Alex Conard, Rieko Ishima, Du-San Baek, John W. Mellors, Ye-Jin Kim, Dimiter S. Dimitrov
Publikováno v:
Cancer Letters. 525:97-107
Neuro-endocrine prostate cancer (NEPC) accounts for about 20% of lethal metastatic castration-resistant prostate cancer (CRPC). NEPC has the most aggressive biologic behavior of all prostate cancers and is associated with poor patient outcome. Effect