Zobrazeno 1 - 10
of 1 185
pro vyhledávání: ''
Autor:
Jinjing Zhong, Miao Xu, Zhengzheng Su, Mengni Zhang, Tianping Yu, Ling Nie, Jing Gong, Xueqin Chen, Ni Chen, Qiao Zhou
Publikováno v:
Cancer Letters. 530:68-84
Glioma-associated oncogene homolog 1 (GLI1) is a core component of the Hedgehog (HH) signalling pathway and is a transcription activator of numerous oncogenes, such as SOX9, VEGFA, BCL2, and CDK2. The complex regulation of GLI1 involves numerous path
Autor:
Maria Christina Cox, Guido Bocci
Publikováno v:
Cancer Letters. 524:144-150
Novel drugs are rapidly moving forward the treatment-paradigm of non-Hodgkin-lymphomas (NHLs). Notwithstanding, especially in aggressive subtypes, chemotherapy remains the pillar of treatment. Indeed, the combination of highly effective Maximum-Toler
Publikováno v:
Cancer Letters. 523:10-28
Tumour angiogenesis is an independent risk factor for bladder cancer (BCa) progression, but viable and promising antiangiogenic targets are understudied. Secretory autophagy has received increasing interest recently, while the roles and executing mec
Autor:
Eric S. Geanes, Sean M. Holloran, Anuradha Roy, Olivia K. Provance, Sumedha Gunewardena, Christy R. Hagan, Scott Weir, Asona Lui, Joan Lewis-Wambi
Publikováno v:
Cancer Lett
Overexpression of interferon induced transmembrane protein-1 (IFITM1) enhances tumor progression in multiple cancers, but its role in triple-negative breast cancer (TNBC) is unknown. Here, we explore the functional significance and regulation of IFIT
Autor:
Marco Macagno, Gianluigi De Renzi, Francesca Belardinilli, Giuseppe Giannini, Enrico Cortesi, Ludovic Barault, Simone Bargiacchi, Salvatore Caponnetto, Paola Grammatico, Irene Bottillo, Paola Gazzaniga, Chiara Nicolazzo, Federica Di Nicolantonio
Publikováno v:
Cancer Letters. 507:89-96
The paucity of targeted treatments available in patients with RAS mutant colorectal cancers contributes to the poor prognosis of this patient group compared to those with RAS wild-type disease. Recent liquid biopsy-driven studies have demonstrated th
Publikováno v:
Cancer Letters. 503:213-219
Chemotherapy for patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, node-negative breast cancer, and with midrange Oncotype DX breast recurrence scores (RS) still needs to be further individualized. To
Autor:
Hidehiko Takigawa, Naoki Yorita, Kazuya Kuraoka, Ryo Yuge, Atsushi Ono, Yasuhiko Kitadai, Shinji Tanaka, Kazuaki Chayama, Toshio Kuwai
Publikováno v:
Cancer Letters. 498:111-120
Despite recent advances in cancer immunotherapy, the efficacy of colorectal cancer (CRC) immunotherapy regimens is limited. This study evaluated the combined effect of an anti-PD-1 antibody and a platelet-derived growth factor receptor inhibitor (ima
Publikováno v:
Cancer Letters. 499:164-174
The Hippo signaling pathway controls cellular processes including growth, homeostasis, and apoptosis. The kinase STK3 acts upstream in this pathway to activate LATS1/2 kinase, which phosphorylates and inactivates the transcriptional coactivators YAP/
Autor:
Xue Wu, Ran Cao, Ao Wang, Xiangxing Kong, Kefeng Ding, Ying Yuan, Wei Lu, Kaihua Liu, Yeting Hu, Qian Xiao, Hua Bao, Xiaonan Wang, Yang W. Shao, Shu Zheng
Publikováno v:
Cancer Letters. 499:201-208
The gut microbiota is closely associated with colorectal neoplasia. While most metagenomics studies utilized fecal samples, circulating bacterial DNA in colorectal neoplasia patients remained unexplored. This proof-of-concept study aims to characteri
Autor:
Jingxin Li, Guosheng Li, Min Ji, Daoxin Ma, Jingjing Ye, Jie Zou, Chunyan Ji, Tao Sun, Yanan Zhao, Yan Wang, Hongchun Wang, Yihua Pang, Fei Lu, Yanping Sun
Publikováno v:
Cancer Letters. 497:178-189
The NLRP3 inflammasome plays a pro-tumorigenic role in various malignancies. However, its potential role in lymphomagenesis remains unclear. In this study, we identified an immunosuppressive state in patients with diffuse large B cell lymphoma (DLBCL