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Autor:
Risheng Que, Xueli Bai, Junye Chen, Tingbo Liang, Guogang Li, Jianying Lou, Yi Wang, Jianxin Wang, Tao Wei, Xiaowei Dang, Xiaoyu Zhang, Xiang Li, Shunliang Gao, Jiaqi Yang, Qi Chen, Lei Zheng, Qi Zhang, Tao Ma
Publikováno v:
Cancer Letters. 452:237-243
The identification of circulating tumor cells (CTCs) relies on epithelial tumor cell markers. In the present study, we aimed to determine whether cell-surface vimentin could be a biomarker to isolate CTCs in pancreatic ductal adenocarcinoma (PDAC). V
Autor:
Stephen J. Freedland, S. Lilly Zheng, Jianfeng Xu, Lauren E. Howard, Tatsuki Koyama, Jay H. Fowke, Qi Dai
Publikováno v:
Cancer Letters. 449:99-105
Recent studies suggest a diet low in dietary magnesium intake or lower blood magnesium levels is linked with increased prostate cancer risk. This study investigates the race-specific link between blood magnesium and calcium levels, or dietary magnesi
Autor:
Enfan Zhang, Qing Yi, Jingsong He, Xi Huang, Mengmeng Dong, Jing Chen, Qiang Shen, Xinling Liu, Haimeng Yan, Zhen Cai, Donghua He, Xing Guo, Gang Wang, Gaofeng Zheng, Xuanru Lin, Qingxiao Chen
Publikováno v:
Cancer Letters. 446:38-48
The interaction of multiple myeloma (MM) cells with macrophages (MΦs) contributes to the pathophysiology of MM. We previously showed that IL-32 is overexpressed in MM patients. The present study was designed to explore the clinical significance of I
Autor:
Bengt Samuelsson, Cristina Gómez, Craig E. Wheelock, Casper J. E. Wahlund, Ana Lukic, Olof Rådmark, Daniel Brodin, Susanne Gabrielsson
Publikováno v:
Cancer Letters. 444:1-8
Tumor-derived exosomes can modulate the cancer microenvironment and induce metastatic spread. Exosomes may carry enzymes for leukotriene (LT) biosynthesis, but the role of exosomal LTs has not been studied in cancer. We isolated exosomes and malignan
Publikováno v:
Cancer Letters. :189-201
TMEM126A is a mitochondrial transmembrane protein, and its functions in breast cancer progression remain unclear. In this study, via the iTRAQ assay using primary and metastatic breast cancer cell models, we found that TMEM126A expression decreased i
Publikováno v:
Cancer Letters. :11-22
In recent years, accumulating evidence has indicated that long non-coding RNAs (lncRNAs) are powerful factors influencing the progression of multiple malignancies. Although a relationship between the lncRNA NEAT1 (nuclear enriched abundant transcript
Publikováno v:
Cancer Letters. 436:119-128
T-cell immunoglobulin domain and mucin domain-4 (Tim-4) is overexpressed in several tumors and is correlated with enhanced tumor development and metastasis. In this study, we investigated the physiological alterations and molecular events related to
Autor:
Cinzia Giordano, Ines Barone, Valentina Vircillo, Daniela Bonofiglio, Balázs Győrffy, Luca Gelsomino, Roberta Tarallo, Giuseppina Bruno, Francesco Romeo, Sebastiano Andò, Antonella Caruso, Antonio Rinaldi, Stefania Catalano
Publikováno v:
Cancer Letters. 437:89-99
Cancer-associated Fibroblasts (CAFs), the principal components of tumor microenvironment, play multiple role in breast cancer progression. We have previously shown an oncosuppressive role of the nuclear Farnesoid X Receptor (FXR) in mammary epithelia
Autor:
Michihiro Suzuki, Hiroyuki Yamamoto, Hideaki Takahashi, S Iwabuchi, Yasushi Sasaki, Masayuki Takagi, Takeshi Niinuma, Hiroshi Yotsuyanagi, Chiaki Okuse, Yasuhito Tanaka, Naoki Matsumoto, Norie Yamada, Ritsuko Oikawa, Takeya Tsutsumi, Takeshi Matsui, Takehito Otsubo, Takashi Tokino, Hideki Wakasugi, Hiromu Suzuki, Noriyuki Akutsu, Hiroshi Nakase, Hajime Sasaki, Yuko Takeba, Shigeru Sasaki, Jong-Hon Kang, Eiichiro Yamamoto, Masayuki Nakano, Yasushi Ariizumi, Masahiro Kai, Hiroshi Kitajima, Fumio Itoh
Publikováno v:
Cancer Letters. 434:91-100
Hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma (HCC). Nucleos(t)ide analogue (NA) therapy effectively reduces the incidence of HCC, but it does not completely prevent the disease. Here, we show that dysregulation of mi
Autor:
Shahnaz Begum, Myriam Loyo, Pauline de Graeff, Carla Rabitti, Maartje G. Noordhuis, Wim Van Criekinge, Roberto Angioli, Maria Luana Poeta, Aditi Chatterjee, Alex Zhavoronkov, Tanusree Sen, Leonel Maldonado, Mohammad O. Hoque, Ate G.J. van der Zee, G. Bea A. Wisman, Vito Michele Fazio, Maté Ongenaert, Mariana Brait, Eugene Makarev, Evgeny Izumchenko, Alvaro Barbosa
Publikováno v:
Cancer letters, 433, 242-251. ELSEVIER IRELAND LTD
Many epigenetically inactivated genes involved in ovarian cancer (OC) development and progression remain to be identified. In this study we undertook an integrated approach that consisted of identification of genome-wide expression patterns of primar