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Autor:
S.A. McGarrigle, Graham P. Pidgeon, Joanne Lysaght, John V. Reynolds, E.P. van der Stok, Emma H. Allott, R. Casey, Jane Howard, Claire L. Donohoe, Narayanasamy Ravi
Publikováno v:
Cancer Letters. 312:62-72
Obesity has been associated with increased incidence and mortality of oesophageal and colorectal adenocarcinoma. Excess central adiposity may drive this association through an altered inflammatory milieu. Utilising a unique adipose tissue bioresource
Autor:
Sanghoon Jheon, Woo Sean Jean, Ji Woong Son, Hoi Young Lee, Hyun Min Cho, Soon Young Park, Kang Jin Jeong, Jaeku Kang, Chang Gyo Park
Publikováno v:
Cancer Letters. 311:29-37
Early detection of lung cancer provides the highest potential for saving lives. To date, no routine screening method enabling early detection is available, which is a key factor in the disease’s high mortality rate. Copy number changes and DNA meth
Publikováno v:
Cancer Letters. 310:216-221
Men are much more likely than women to develop head and neck squamous cell carcinoma (HNSCC), a discrepancy that is insufficiently explained by gender differences in smoking and alcohol consumption. It has been hypothesized that differential hormonal
Publikováno v:
Cancer Letters. 310:9-14
The aim of this study was to investigate CD99 as a new marker to characterize solid pseudopapillary tumors (SPTs), and to determine a specific panel of markers to identify the disease. We analyzed the clinicopathological characteristics and immunohis
Autor:
Kanji Yamaguchi, Tomoki Nakajima, Yoshito Itoh, Hideki Fujii, Atsushi Umemura, Takeshi Nishimura, Takeshi Okanoue, Masahito Minami, Chihiro Yokomizo, Hironori Mitsuyoshi, Kohichiroh Yasui, Toshikazu Yoshikawa, Nozomi Tochiki
Publikováno v:
Cancer Letters. 310:140-147
P300 impacts the transcription of several genes involved in biological behavior of human malignancies including hepatocellular carcinomas (HCC). We found p300 is highly expressed in 47% of surgically resected HCC specimens by immunohistochemistry, wh
Autor:
Marloes C. de Kok, Kirstine M. Sveje, Wout G.N. Mares, Theo M. de Kok, Gunter G. C. Kuhnle, Ad A.M. Masclee, Leopold G.J.B. Engels, Dennie G. A. J. Hebels, Carla B.E.M. Vleugels-Simon, Marieke Pierik, Jos C. S. Kleinjans, Marcel H. M. van Herwijnen
Publikováno v:
Cancer Letters, 309(1), 1-10. Elsevier Ireland Ltd
Endogenous formation of N-nitroso compounds (NOCs), which are known animal carcinogens, could contribute to human carcinogenesis but definitive evidence is still lacking. To investigate the relevance of NOCs in human colorectal cancer (CRC) developme
Autor:
Yoshiharu Ohaki, Masahito Hagio, Tetsushi Yamamoto, Nando Nakazawa, Yoko Matsuda, Kiyoko Kawahara, Kazuya Yamahatsu, Tomoko Seya, Zenya Naito, Wei-Xia Peng, Toshiyuki Ishiwata
Publikováno v:
Cancer Letters. 309:209-219
Fibroblast growth factor receptor 2 (FGFR2) is considered a novel therapeutic target for various cancer. We used a silencing strategy to clarify the effect of reduced FGFR2 expression in human colorectal cancer (CRC) cells. The invasive front of canc
Autor:
Takeshi Suda, Satoshi Yamagiwa, Atsunori Tsuchiya, Masaaki Takamura, Hiroteru Kamimura, Yutaka Aoyagi, Yasushi Tamura, Minoru Nomoto
Publikováno v:
Cancer Letters. 309:95-103
We analyzed hepatocellular carcinoma (HCC) with progenitor cell features using hepatic stem/progenitor cell marker neural cell adhesion molecule (NCAM). Approximately 8.3% of the operated HCC cases expressed NCAM, and 22.3% of the HCC patients had so
Autor:
Guan-Chao Lai, Shenming Wang, Dan-Dan Yu, Wei-Qing Chen, Ze-Fang Ren, Feng-Xi Su, Ying Lin, Er-Wei Song, Lu-Ying Tang, Jian-Rong He
Publikováno v:
Cancer Letters. 309:128-136
We investigated IgA and IgG levels against EBV viral capsid antigen (VCA) and nuclear antigen-1 (EBNA-1) in serum of 223 women with breast cancer (BC) and 309 controls in Guangzhou, China. VCA IgA levels were significantly associated with an elevated
Autor:
Shinji Uemoto, Takafumi Machimoto, Naoya Sasaki, Kentaro Yasuchika, Masatoshi Kajiwara, Takamichi Ishii, Norio Nakatsuji, R. Kamimura, Iwao Ikai, Hirofumi Suemori
Publikováno v:
Cancer letters. 308(2):152-161
We aimed to demonstrate the existence of cancer stem cells in human pancreatic cancer, and to clarify that they are alpha-fetoprotein (AFP) producing cells. Six cell lines derived from human pancreatic cancers were examined, and AsPC-1 and PANC-1 wer