Zobrazeno 1 - 10
of 143
pro vyhledávání: ''
Autor:
Jinjing Zhong, Miao Xu, Zhengzheng Su, Mengni Zhang, Tianping Yu, Ling Nie, Jing Gong, Xueqin Chen, Ni Chen, Qiao Zhou
Publikováno v:
Cancer Letters. 530:68-84
Glioma-associated oncogene homolog 1 (GLI1) is a core component of the Hedgehog (HH) signalling pathway and is a transcription activator of numerous oncogenes, such as SOX9, VEGFA, BCL2, and CDK2. The complex regulation of GLI1 involves numerous path
Publikováno v:
Cancer Letters. 499:164-174
The Hippo signaling pathway controls cellular processes including growth, homeostasis, and apoptosis. The kinase STK3 acts upstream in this pathway to activate LATS1/2 kinase, which phosphorylates and inactivates the transcriptional coactivators YAP/
Autor:
Jingxin Li, Guosheng Li, Min Ji, Daoxin Ma, Jingjing Ye, Jie Zou, Chunyan Ji, Tao Sun, Yanan Zhao, Yan Wang, Hongchun Wang, Yihua Pang, Fei Lu, Yanping Sun
Publikováno v:
Cancer Letters. 497:178-189
The NLRP3 inflammasome plays a pro-tumorigenic role in various malignancies. However, its potential role in lymphomagenesis remains unclear. In this study, we identified an immunosuppressive state in patients with diffuse large B cell lymphoma (DLBCL
Autor:
Da Song, Fuqing Hu, Jingqin Lan, Li Sun, Zhenlin Hou, Guihua Wang, Yongdong Feng, Xuelai Luo, Feng Xu, Junbo Hu, Jing Wang
Publikováno v:
Cancer Letters. 487:63-73
The histone methyltransferase SETDB1 catalyzes the addition of methyl groups to histone H3 at lysine 9, and upregulation of SETDB1 is associated with poor prognosis in cancer patients. Here, we describe how overexpression of SETDB1 contributes to col
Autor:
Bin Zhou, Moli Huang, Ningyue Zhang, Lei Zhang, Fengying Wu, Zhiming Zhao, Shaomu Chen, Yali Chen, Anqi Li
Publikováno v:
Cancer Letters. 485:14-26
The Insulin-like growth factor-1/Insulin-like growth factor-1 receptor (IGF1/IGF1R) axis contributes to immunosuppression during tumor progression; however, the underlying mechanism remains unclear. In the present study, we found that IGF1 stimulatio
Autor:
Hailong Wang, Han Wang, Qian Dong, Mei-Na Su, Yan Zhuang, Hui Zhang, Yong Liu, Xiaowei Wang, Wei Lu, Da Jiang, Jie Yue, Yunlong Cui, He Ren, Wen-Hua Jiang, Pengfei Liu, Jia-Hui Mi, Zanmei Xu, Caijuan Tian, Zhenzhen Zhang
Publikováno v:
Cancer Letters. 470:181-190
Most cancers are caused by somatic mutations. Some common mutations in the same cancer type can form a "signature" to specifically predict the prognosis or to distinguish it from other cancers. In this study, 710 somatic cell mutations were identifie
Autor:
Ying Yuan, Zixian Liu, Yujun Chen, Huihui Zhang, Hongfeng Yuan, Man Zhao, Lei Liu, Jinyan Feng, Xiaodong Zhang, Guang Yang, Jiapei Wang, Haolin Yun, Yanan Bu
Publikováno v:
Cancer Letters. 470:54-63
Abnormal lipid metabolism plays crucial roles in the development of cancer. Spindlin 1 (SPIN1) involving the process of spindle organization and chromosomal stability serves as an important player in the carcinogenesis. In this study, we try to ident
Autor:
Andelko Hrzenjak, Maximilian Mack, Katrin Panzitt, Sandra Schein, Luka Brcic, Horst Olschewski, Carina Seidl, Karin Kornmueller, Alexandra Bertsch, Katharina Leithner, Felix Prinz
Publikováno v:
Cancer Letters. 469:266-276
Lung cancer is one of the deadliest cancers worldwide. Late diagnosis at an advanced, inoperable stage makes chemotherapy a treatment of choice, yet, with low response rates. The hedgehog signaling pathway (HHSP) is often reactivated in cancer. We id
Autor:
Antonio Bobbio, Zherui Wu, Philippe Icard, Filippo Lococo, Ludovic Fournel, Marco Alifano, Diane Damotte, Jean Trédaniel, Patricia Forgez, Geoffroy Boulle, Evelyne Ségal-Bendirdjian, Nicolas Stadler
Publikováno v:
Cancer Letters
Cancer Letters, Elsevier, 2019, 464, pp.5-14
Cancer Letters, Elsevier, 2019, 464, pp.5-14
International audience; The number of clinical protocols testing combined therapies including immune check-point inhibitors and platinum salts is currently increasing in lung cancer treatment, however preclinical studies and rationale are often lacki
Autor:
Daiming Fan, Suzhen Yang, Yirong Jin, Xiaoliang Gao, Yi Chu, Weijie Wang, Yongzhan Nie, Hao Liu, Mingzuo Jiang, Jiayao Wang, Yuying Han, Ahui Fan, Xin Fu, Wenjiao Li, Di Chen, Jiayi Cao, Wenyao Zhang
Publikováno v:
Cancer letters. 524
Pancreatic ductal adenocarcinoma (PDAC) has the highest fatality rate of any solid tumor, with a five-year survival rate of only 10% in the USA. PDAC is characterized by early metastasis. More than 50% of patients present with distant metastases at t