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Autor:
Hailing Cheng, Pixu Liu, Li Li, Zhiwei Tao, Zundong Liu, Yichao Liu, Xiaolin Sang, Chunhua Rui
Publikováno v:
Cancer Letters. 518:82-93
Despite HER2-targeted cancer treatments have provided considerable clinical benefits, resistance to HER2-targeted agents will inevitably develop. Targeting non-oncogene vulnerabilities including endoplasmic reticulum (EnR) stress has emerged as an at
Autor:
Zhangfeng Zhong, Yau-Tuen Chan, Sha Li, Feiyu Chen, Hor-Yue Tan, Cheng Zhang, Yibin Feng, Wei Guo, Ning Wang
Publikováno v:
Cancer Letters. 475:109-118
ID1 is an oncogenic factor in cancer, but its role in relation to drug sensitivity is unclear. This study aimed to investigate the role of ID1 in drug sensitivity in non-small cell lung cancer (NSCLC). ID1 overexpression in NSCLC cells harboring eith
Publikováno v:
Cancer Letters. 468:88-101
Dysregulation of circular RNA Foxo3 (circFoxo3) has been reported to be involved in breast cancer and non-small lung cancer progression. However, little is known about the role of circFoxo3 in prostate cancer, which the present study seeks to investi
Autor:
James W. Lillard, Guru Sonpavde, Sanjay R. Jain, Neeraj Kapur, Sejong Bae, Hina Mir, Shailesh Singh
Publikováno v:
Cancer Lett
Molecular reprogramming in response to chemotherapeutics leads to poor therapeutic outcomes for prostate cancer (PCa). In this study, we demonstrated that CXCR6-CXCL16 axis promotes DTX resistance and acts as a counter-defense mechanism. After CXCR6
Autor:
Norihiko Sugisawa, Kentaro Miyake, Katsuhiro Hayashi, Hiroaki Kimura, Norio Yamamoto, Sahar Razmjooei, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Robert M. Hoffman, Hiroyuki Tsuchiya, Hiromichi Oshiro, Zhiying Zhang, Shree Ram Singh, Michael Bouvet
Publikováno v:
Cancer Letters. 451:122-127
Olaratumab (OLA), a monoclonal antibody against platelet-derived growth factor receptor alpha (PDGFRα), has recently been used against soft-tissue sarcoma (STS) combined with doxorubicin (DOX), with limited efficacy. The goal of the present study wa
Autor:
Qinhong Luo, Qinkai Li, Wenlv Zheng, Junmin Quan, Yibo Zhang, Xin Zeng, Wanxuan Li, Jianwen Pei
Publikováno v:
Cancer Letters. 450:110-122
Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a key regulator in innate immunity and has emerged as a promising drug target in cancer treatment, but the utility of this pathway in therapeutic development is complica
Autor:
Stig Linder, Karthik Selvaraju, Xiaonan Zhang, Padraig D'Arcy, Slavica Brnjic, Magdalena Mazurkiewicz, Ellin-Kristina Hillert, Arjan Mofers, Amir Ata Saei, Roman A. Zubarev
Publikováno v:
Cancer Letters. 448:70-83
Proteasome inhibitors have been shown to induce cell death in cancer cells by triggering an acute proteotoxic stress response characterized by accumulation of poly-ubiquitinated proteins, ER stress and the production of reactive oxygen species. The a
Autor:
Kakuhiro Yamaguchi, Masashi Namba, Hironobu Hamada, Shintaro Miyamoto, Shinjiro Sakamoto, Nobuoki Kohno, Yohei Okamoto, Taku Nakashima, Takeshi Masuda, Kazunori Fujitaka, Yasushi Horimasu, Noboru Hattori, Hiroshi Iwamoto
Publikováno v:
Cancer Letters. 442:31-39
Polymorphic epithelial mucin (MUC1) is generally overexpressed on the surface of most adenocarcinomas including breast cancer. MUC1 is associated with chemotherapeutic resistance and immune evasion of cancer cells; however, the association between MU
Autor:
Kuo-Yen Huang, Shih-Han Kao, Ya-Hsuan Chang, Chia-Yi Lin, Wei-Chia Chung, Chih-Chun Shih, Jin-Yuan Shih, Chih-An Lin, Yi-Chun Lin, Yih-Leong Chang, Pan-Chyr Yang, Chao-Chi Ho, Shuenn-Chen Yang
Publikováno v:
Cancer letters. 508
The development of a new generation of tyrosine kinase inhibitors (TKIs) has improved the treatment response in lung adenocarcinomas. However, acquired resistance often occurs due to new epidermal growth factor receptor (EGFR) mutations. In particula
Autor:
Thaynan Cunha Vieira, Alex Rafacho, Geovanni Dantas Cassali, José Cláudio Fonseca Moreira, Daniel Augusto Gasparin Bueno Mendes, Ana Paula Vargas Garcia, Maciel Alencar Bruxel, André Báfica, Marcelo Falchetti, Daniel Pens Gelain, Alexander J.R. Bishop, Raquel Nascimento das Neves, Rosângela Mayer Gonçalves, Jonathan Paulo Agnes, Alfeu Zanotto-Filho, Marina Delgobo, Nauana Somensi, Tuany Casagrande
Publikováno v:
Cancer letters. 502
Obesity is a major risk factor for breast cancer, especially in post-menopausal women. In the breast tissue of obese women, cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2) production has been correlated with inflammation and local estrogen