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Publikováno v:
Cancer Letters. 500:1-10
Osteosarcoma (OS) is the most common primary malignancy of the bone and has a high propensity for local invasion and metastasis. Although combining surgery with chemotherapy has immensely improved the outcomes of osteosarcoma patients, the prognosis
Autor:
Xue Wu, Ran Cao, Ao Wang, Xiangxing Kong, Kefeng Ding, Ying Yuan, Wei Lu, Kaihua Liu, Yeting Hu, Qian Xiao, Hua Bao, Xiaonan Wang, Yang W. Shao, Shu Zheng
Publikováno v:
Cancer Letters. 499:201-208
The gut microbiota is closely associated with colorectal neoplasia. While most metagenomics studies utilized fecal samples, circulating bacterial DNA in colorectal neoplasia patients remained unexplored. This proof-of-concept study aims to characteri
Autor:
Torsten E. Reichert, I Ugele, Rosemarie Krupar, Peter J. Siska, Katrin Singer, Felix Nieberle, Katrin Peter, Michael Gerken, Almut Brand, Philipp Beckhove, Gerrit Spanier, Steffen Spoerl, Marina Kreutz, Petra Rümmele, Johannes K. Meier, Kathrin Renner, Sandra Schmidhofer, L Symeou
Publikováno v:
Cancer Letters. 499:209-219
Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression
Publikováno v:
Cancer Letters. 477:60-69
Betel quid (BQ) and areca nut use are at risk of cancer. This review includes the latest evidence of carcinogenesis caused by BQ exposure, suggests possible prevention strategies. We conducted a systematic literature search in the PubMed and Web of S
Autor:
Yin Zongyi, Li Xiaowu
Publikováno v:
Cancer Letters. 470:8-17
Despite significant research efforts, only a few treatment approaches have been developed for hepatocellular carcinoma (HCC). In recent years, immune checkpoint inhibitors (anti-PD-1, anti-PD-L1, and anti-CTLA-4 antibodies) have exhibited potential t
Autor:
Francesco Sclafani, Giacomo Bregni, Amélie Deleporte, Tugba Akin Telli, Alain Hendlisz, Silvia Camera
Publikováno v:
Cancer Letters. 469:142-150
Oesophago-gastric cancers (OGCs) are aggressive tumours. While better peri-operative strategies, increased number of cytotoxic agents and availability of targeted therapies have improved survival, there remains an unmet need for novel treatment appro
Publikováno v:
Cancer Letters. 459:240-247
Discovery of activating mutations in epidermal growth factor receptor (EGFR) as a predictive biomarker for first-generation EGFR tyrosine kinase inhibitors (TKIs) has initiated an era of precision oncology for the treatment of advanced EGFR-mutant no
Autor:
Myriam Chalabi, Jolanda M. van Dieren, Liudmila L. Kodach, W J Koemans, Johanna W. van Sandick
Publikováno v:
Cancer Letters. 442:279-286
Gastric adenocarcinoma and esophageal adenocarcinoma are aggressive cancers with a poor prognosis. Therefore, new therapeutic strategies are needed, especially for patients refractory to conventional treatment. Cancer immunotherapy (CIT), is a promis
Autor:
Karen Tan, Michael Vito Martin Blanco, Sai Mun Leong, Zizheng Kee, Patrick Vincent Caramat, Thomas I-Peng Soh, Wei Peng Yong, Wai Kit Cheong, James Teo, Evelyn Siew-Chuan Koay, Angela Pang
Publikováno v:
Cancer Letters. 423:1-8
We evaluated the changes in CTC count and CTC-associated miRNAs during the course of chemotherapy in patients with metastatic colorectal cancer. Blood samples were collected from 9 metastatic colorectal cancer patients prior to chemotherapy and at ev
Autor:
Robert E. Emerson, Peter C. Hollenhorst, Sunil Tomar, Joshua Scantland, Subramanyam Dasari, Zahir Sheikh, Joshua P. Plotnik, James Haley, Dean Lenz, Anirban K. Mitra
Publikováno v:
Cancer Letters. 414:190-204
Metastatic colonization involves paracrine/juxtacrine interactions with the microenvironment inducing an adaptive response through transcriptional regulation. However, the identities of transcription factors (TFs) induced by the metastatic microenvir