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Autor:
Vanessa Davies, Ioannis A. Voutsadakis
Publikováno v:
Cancer Investigation. 38:94-101
Background: Amplification of the centromeric region of chromosome 17 (CEP17) as measured by In Situ Hybridization (ISH) of the CEP17 probe is used clinically as part of the ISH assay for HER2 statu...
Autor:
Sabhiya Majid, Ajaz Ahmad Waza, Waseem Qureshie, Rawoof Ahmad Malik, Showkat Jeelani, Showkat Ahmad Kadla, Shiekh Ishaq, Iram Shabir, Arif Akbar Bhat, Akbar Masood, Hilal Ahmad Wani
Publikováno v:
Cancer investigation. 35(2)
Epigenetic alterations, in addition to multiple gene abnormalities, are involved in the genesis and progression of human cancers. Gastrointestinal tract (GIT) cancer is a major medical and economic burden worldwide. Aberrant methylation of CpG island
Autor:
Luca Galli, Francesco Cognetti, Paolo A. Ascierto, Carolina Cimminiello, Gaetana Rinaldi, Maria Grazia Bernengo, Gian Carlo Antonini Cappellini, Ester Simeone, Vanna Chiarion Sileni, Michele Guida, Alessandro Testori, Michele Maio, Michele Del Vecchio, Paola Queirolo, Francesco De Rosa, Fabrizio Carnevale-Schianca, Virginia Ferraresi, Ruggero Ridolfi, Paolo Marchetti, Mario Mandalà
Publikováno v:
Cancer Investigation. 32:144-149
Of 93 patients with pretreated, BRAFV600 mutation-positive advanced melanoma who received vemurafenib or dabrafenib before (n = 45) or after (n = 48) treatment with ipilimumab 3 mg/kg, median overall survival (mOS) from first treatment was 9.9 and 14
Publikováno v:
Cancer Investigation. 31:639-644
The role of genetic alterations in PIK3CA gene has not been fully explored in ovarian clear cell carcinoma (OCCC). The present study was undertaken to assess mutations and amplifications of exons 9 and 20 of PIK3CA in 51 Chinese OCCC patients. Activa
Autor:
Ricardo de Sá Bigni, Sérgio de Oliveira Romano, Gelcio Luiz Quintella Mendes, Raquel Ciuvalschi Maia, Roberta Soares Faccion, Lidia Maria Magalhães de Rezende
Publikováno v:
Cancer Investigation. 30:404-414
Centroblastic diffuse large B cell lymphoma (DLBCL) samples were analyzed by immunohistochemistry to evaluate the expression of p53, Bcl-2, Survivin, XIAP, and Ki-67. Survivin was the only protein which expression exhibited a trend for impact in prog
Autor:
Jamal Shamsara, Hamid Reza Raziee, Marzieh Lotfi, Kamran Ghaffarzadegan, Saeed Rahighi, Sima Afsharnezhad, Samaneh Sharif, Javad Behravan, Afshin Moradi
Publikováno v:
Cancer Investigation. 27:825-829
O(6)-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that removes alkyl groups from the O(6) position of guanine. MGMT is transcriptionally silenced by promoter hypermethylation in several human neoplasia. We used methylation-specif
Publikováno v:
Cancer Investigation. 15:217-223
ADP-ribosylation of human serum proteins was studied in various groups of disorders. In most of these groups, the extent of ADP-ribosylation did not show a divergence from the group of normal controls. Neoplastic diseases revealed, however, a unique
Autor:
Ming Zhao, Ni Yin, Bangliang Yin, Fenglei Yu, Jianguo Hu, Chen Chen, Bin He, Qianjin Lu, Baoxiang Wang, Yunchang Yuan
Publikováno v:
Cancer investigation. 29(8)
To investigate whether alterations in histone modifications occur in esophageal squamous cell carcinoma (ESCC), we measured histone H3/ H4 acetylation and H3K4/H3K27 methylation levels, as well as the expression of chromatin modifier genes in tumor a
Autor:
Toshio Yawata, Kae Chang Park, Eiichi Nakai, Ayano Kumazawa, Keiji Shimizu, Takahiro Chihara, Hiromichi Nakabayashi
Publikováno v:
Cancer investigation. 27(9)
We established a cancer stem (CS) cell line, U87CS, by means of spheroid culture of U87MG cells derived from glioblastoma (GBM) in neuronal stem cell medium. U87CS cells presented positive immunohistochemical staining for multidrug resistance (MDR)1
Autor:
Ivan Bièche, Ingrid Laurendeau, Delia Garrido, Nicky D'Haene, Armando Basso, Marcela Maria Ferrer, Patricia Ciavarelli, Isabelle Salmon, Michel Vidaud, Irene Szijan
Publikováno v:
Cancer investigation. 27(6)
ErbB family receptors mediate major cellular functions implied in tumorigenesis, though their role in meningiomas was not thoroughly studied. Meningiomas represent 30% of primary cranial tumors, are mostly benign, and prevail in the second half of li