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Publikováno v:
Cancer investigation. 39(6-7)
The strong association between inflammation and cancer is reflected by the high interleukin-6 (IL-6) levels in the tumor microenvironment, where it promotes carcinogenesis by regulating all hallmarks of cancer and multiple signaling pathways. In this
Publikováno v:
Cancer investigation. 39(1)
Abnormal p53 immunohistochemical pattern (p53-AP) including overexpression, complete absence and heterogeneity is surrogate of TP53 mutation. Using 742 cases of colorectal cancer (CRC), we show p53-AP is more common among type 2 diabetes (T2DM) patie
Publikováno v:
Cancer Investigation. 32:368-374
Lymphoid enhancer-binding factor 1 (LEF1) has been regarded as an important gene for carcinogenesis in many malignancies, however, the role of LEF1 in the progression of human renal cell carcinoma (RCC) has not been well studied. In this study, we in
Publikováno v:
Cancer Investigation. 31:639-644
The role of genetic alterations in PIK3CA gene has not been fully explored in ovarian clear cell carcinoma (OCCC). The present study was undertaken to assess mutations and amplifications of exons 9 and 20 of PIK3CA in 51 Chinese OCCC patients. Activa
Autor:
Manlio Vinciguerra, Gianluigi Mazzoccoli, Ada Piepoli, Valerio Pazienza, Giorgia Benegiamo, Anna Panza, Maria Rosa Valvano, Angelo Andriulli
Publikováno v:
Cancer Investigation. 30:98-105
SIRT1 and the clock genes are involved in carcinogenesis. We evaluated SIRT1 expression in 19 human colorectal cancer (CRC) specimens and clock gene expression in SIRT1-overexpressing CaCo2 and SW480 cells. In CRC, SIRT1 mean expression level was dec
Publikováno v:
Cancer Investigation. 27:836-843
Fas-associated protein with death domain (FADD) plays a major role in the execution of apoptosis. Attenuation of apoptosis is a hallmark of cancer. Through systemic examination of FADD in renal cell carcinoma (RCC) and adjacent nontumor kidney tissue
Autor:
Robert W. Lea, Gareth Roberts, Leroy Alexander Shervington, Nichola Cruickshanks, Amal Shervington, Timothy Dawson
Publikováno v:
Cancer Investigation. 26:900-904
Despite studies suggesting a role for HSP90alpha in tumorigenesis, there are no reports as to its expression in normal human brain tissue. In this study, the expression of HSP90alpha was evaluated in both cell lines (3 gliomas and 2 controls) and bra
Publikováno v:
Cancer investigation. 32(2)
We investigated the effects of bisphosphonate (BP) on oxidative stress levels in blood of patients with cancer. In total, 19 patients with cancer and 21 healthy subjects were included in the study. BP was intravenously administrated to the participan
Publikováno v:
Cancer investigation. 29(4)
Somatic mutations of phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) play an important role in tumorigenesis. Using PCR-SSCP, followed by sequencing, we examined the PIK3CA gene over the previously identified mutational hotspots in a
Autor:
Levent Bekir Beder, Kursat Oguz Yaykasli, Mehmet Gunduz, Ryo Tamamura, Esra Gunduz, Mahmoud Al Sheikh Ali, Noboru Yamanaka, Naoki Katase, Kenji Shimizu, Hitoshi Nagatsuka
Publikováno v:
Cancer Investigation. :1-1
Head and neck squamous cell carcinoma (HNSCC) is a frequently occurring cancer worldwide. Dickkopf (Dkk)-1 gene is suggested to function as tumor suppressor gene (TSG) in several kinds of malignancies. In this study, we performed loss of heterozygosi