Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Haydn T. Kissick"'
Autor:
Bassel F. El-Rayes, Walid L. Shaib, Bradley C. Carthon, Haydn T. Kissick, David H. Lawson, R. Donald Harvey, Mehmet Akce, Colleen Lewis, Viraj A. Master, Christina Wu, Yuan Liu, Mehmet Asim Bilen, Rathi N. Pillai, Julie M. Shabto, Ragini R. Kudchadkar, Hannah Collins, Suresh S. Ramalingam, Taofeek K. Owonikoko, Olatunji B. Alese, Dylan J. Martini, Conor E. Steuer
Publikováno v:
Cancer Immunology Research. 7:B176-B176
Background: There are now six approved immune checkpoint inhibitors for several different malignancies including melanoma, head and neck cancer, lung cancer, and renal cell carcinoma. Given the increased number of available immunotherapeutic agents,
Publikováno v:
Cancer Immunology Research. 7:A196-A196
CD8+ T-cells are responsible for detection and killing of hosT-cells expressing non-self proteins. Upon antigen persistence, as in cancer or chronic viral infection, antigen-specific CD8+ T-cells lose their effector function, a phenomenon known as T-
Publikováno v:
Cancer Immunology Research. 4:B142-B142
Exhaustion of CD8+ T lymphocytes is a major barrier to effective clearance of chronic viral infection and cancer by the immune system. Transcriptional changes underlie the expansion and differentiation of a naive CD8+ T cell into various effector sub