Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Bartosz, Chmielowski"'
Autor:
Emma Taylor, David Elashoff, Paul C. Tumeh, Christina L. Harview, Andrew Tucker, Reinhard Dummer, Michael Rosenblum, Kimberly Loo, Matthew F. Krummel, Simone M. Goldinger, Eduardo V. Sosa, Peter D. Boasberg, Omid Hamid, Janis M. Taube, Jeremy Chang, Bartosz Chmielowski, Pamela N. Munster, Juan C. Osorio, Katy K. Tsai, Adi Nosrati, Phillip J. Sanchez, Dan L. Nguyen-Kim, Neharika Khurana, Matthew D. Hellmann, Tristan Grogan, Matthew A. Gubens, I. Peter Shintaku, Alain Algazi, Nooriel Banayan, Robert H. Pierce, Adil Daud, Edward B. Garon, Jimmy Hwang, Nathan Handley
Publikováno v:
Cancer immunology research, vol 5, iss 5
We explored the association between liver metastases, tumor CD8+ T-cell count, and response in patients with melanoma or lung cancer treated with the anti-PD-1 antibody, pembrolizumab. The melanoma discovery cohort was drawn from the phase I Keynote
Autor:
Janet C. Siebert, Antoni Ribas, Christine Kivork, Dana Pe'er, Bartosz Chmielowski, Jesse M. Zaretsky, Thinle Chodon, Paula Kaplan-Lefko, Begoña Comin-Anduix, Earl Avramis, Andrew E. Cornish, John A. Glaspy, Paul C. Tumeh, Elizabeth Seja, Daniel Sanghoon Shin, Xiaoyan Wang, Juliet Wairimu Frederiksen
Publikováno v:
Ribas, A, Shin, D S, Zaretsky, J, Frederiksen, J W, Cornish, A, Avramis, E, Seja, E, Kivork, C, Siebert, J, Kaplan-Lefko, P, Wang, X, Chmielowski, B, Glaspy, J A, Chodon, T, Tumeh, P C, Pe'er, D & Comin-Anduix, B 2016, ' PD-1 Blockade Expands Intratumoral Memory T Cells ', Cancer Immunology Research, vol. 4, no. 3, pp. 194-203 . https://doi.org/10.1158/2326-6066.CIR-15-0210
Cancer immunology research, vol 4, iss 3
Cancer immunology research, vol 4, iss 3
Tumor responses to programmed cell death protein 1 (PD-1) blockade therapy are mediated by T cells, which we characterized in 102 tumor biopsies obtained from 53 patients treated with pembrolizumab, an antibody to PD-1. Biopsies were dissociated, and
Autor:
I. Peter Shintaku, Christopher T. Denny, Theodore S. Nowicki, Paul C. Tumeh, Rong Rong Huang, Antoni Ribas, Xiaoyan Wang, Arun S. Singh, Bartosz Chmielowski, Ryan Akiyama, Noah Federman
Publikováno v:
Cancer immunology research, vol 5, iss 2
Nowicki, TS; Akiyama, R; Huang, RR; Shintaku, IP; Wang, X; Tumeh, PC; et al.(2017). Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma. CANCER IMMUNOLOGY RESEARCH, 5(2), 118-126. doi: 10.1158/2326-6066.CIR-16-0148. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5jb9r2w2
Nowicki, TS; Akiyama, R; Huang, RR; Shintaku, IP; Wang, X; Tumeh, PC; et al.(2017). Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma. CANCER IMMUNOLOGY RESEARCH, 5(2), 118-126. doi: 10.1158/2326-6066.CIR-16-0148. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5jb9r2w2
Tumors expressing programmed death ligand 1 (PD-L1) interact with the corresponding negative-signal generating immune receptor on the surface of CD8 T cells, PD-1, thereby suppressing antitumor activity. Therapeutics blocking this interaction have sh