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Autor:
Mohammed G. Ghonime, Kevin A. Cassady
Publikováno v:
Cancer Immunology Research. 6:1499-1510
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft-tissue sarcomas resistant to most cancer treatments. Surgical resection remains the primary treatment, but this is often incomplete, ultimately resulting in high mortality and morb
Autor:
Raghu Kalluri, Chanjuan Shi, Valerie M. Weaver, Anna Chytil, Harold L. Moses, Fei Ye, Philip Owens, Sergey V. Novitskiy, Michael W. Pickup, Agnieszka E. Gorska
Publikováno v:
Cancer immunology research, vol 5, iss 9
The survival rate for pancreatic ductal adenocarcinoma (PDAC) remains low. More therapeutic options to treat this disease are needed, for the current standard of care is ineffective. Using an animal model of aggressive PDAC (Kras/p48TGFβRIIKO), we d
Autor:
Giselle Singer, Ayush Chandra, Rui Chang, Sharon Rose, Branden Lau, Jaya Sarin Pradhan, Larisa J. Geskin, Michael Moore, Megan H. Trager, Yvonne M. Saenger, Margaret Bogardus, Kuixi Zhu, Robyn D. Gartrell-Corrado, Emanuelle M. Rizk, Ben Fullerton, Gary Goldenbery
Publikováno v:
Cancer Immunology Research. 9:PO063-PO063
Background: The presence of actinic keratoses (AKs) increases a patient’s risk of developing squamous cell carcinoma (SCC) by greater than six-fold. It is difficult to predict which AKs will progress to become SCC, and topical treatments such as im
Publikováno v:
Cancer Immunology Research. 5:94-99
Inflammation affects all stages of tumorigenesis. A key signaling pathway leading to acute and chronic inflammation is through activation of the caspase-1 inflammasome. Inflammasome complexes are assembled on activation of certain nucleotide-binding
Autor:
Jennifer S. Lee, Agnieszka Denslow, Brian B. Haines, Christophe Quéva, Michael Ball, Lorenz Ponce, Caroline Webb, Jacqueline Gursha, Daniel Wambua, Cecilia Kwong, Finer Mitchell H, Michael Paglia, Prajna Behera, Judith Jacques, Lorena Lerner, Allison Colthart, Lingxin Kong, Peter Grzesik, Terry Farkaly, Laura Viggiano Salta, Edward M. Kennedy, Caity Montagna
Publikováno v:
Cancer Immunology Research. 8:B23-B23
Although oncolytic viruses have shown clinical efficacy for local treatment of cancerous tumors, the ability to induce immune-mediated regression to visceral lesions is not robust. Immune checkpoint modulation has been efficacious in a fraction of ca
Publikováno v:
Cancer Immunology Research. 8:A87-A87
Immunotherapy targeting the programmed cell death ligand 1/programmed cell death protein 1 (PD-L1/PD-1) pathway using antibodies is clinically effective in treating a spectrum of cancers. Acetaminophen (AAP) has shown antitumor and/or chemo-enhancing
Autor:
Niklas von Spreckelsen, Pavel Ivanov, E. Antonio Chiocca, Ruben Ferrer-Luna, Quazim A. Alayo, Sean E. Lawler, Khalid Shah, Hiroshi Nakashima, Rameen Beroukhim, Keith L. Ligon, Marco Mineo, Shawn M. Lyons, Paul A. Anderson, Jasneet Kaur Khalsa, Hirotaka Ito
Publikováno v:
Cancer Immunology Research. 8:B46-B46
Long noncoding RNAs (lncRNAs) are key regulators of gene expression both in physiologic and pathologic conditions. Although the role of lncRNAs in tumorigenesis is now emerging, their function in cancer-mediated immunosuppression remains unexplored.
Publikováno v:
Cancer Immunology Research. 8:B57-B57
Objective: Non-small cell lung cancer (NSCLC) patients with specific EGFR mutations benefited from the emergence of EGFR tyrosine kinase inhibitors (EGFR-TKIs). Unfortunately, almost all cases eventually recrudesced after a median of 10 months. Thera
Autor:
Bryan Belikoff, Michail V. Sitkovsky, Dmitriy Lukashev, Akio Ohta, Robert G. Abbott, Stephen M. Hatfield
Publikováno v:
Cancer Immunology Research. 2:598-605
Hypoxia-driven, A2A adenosine receptor (A2AR)–mediated (hypoxia–A2-adenosinergic), T-cell–autonomous immunosuppression was first recognized as critical and nonredundant in protecting normal tissues from inflammatory damage and autoimmunity. How
Autor:
Judy Lieberman, Justin Kim, Hao Wu, Xuemei Luo, Jianbin Ruan, Shiyu Xia, Jun Hu, Xing Liu, Jingxia Zhao
Publikováno v:
Cancer Immunology Research. 7:A132-A132
Inflammasomes are multiprotein signaling scaffolds that assemble in response to invasive pathogens and sterile danger signals to activate inflammatory caspases (1/4/5/11), which trigger inflammatory death (pyroptosis) and processing and release of pr