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Autor:
Ryusaku Matsumoto, Masaaki Yamamoto, Genzo Iguchi, Shin Urai, Hidenori Fukuoka, Wataru Ogawa, Kentaro Suda, Hiroki Shichi, Keitaro Kanie, Yutaka Takahashi, Hironori Bando, Yasunori Fujita
Publikováno v:
Cancer Immunology, Immunotherapy
Background Immune checkpoint inhibitors (ICIs) as a cancer immunotherapy have emerged as a treatment for multiple advanced cancer types. Because of enhanced immune responses, immune-related adverse events (irAEs), including endocrinopathies such as h
Publikováno v:
Cancer Immunology, Immunotherapy
Monocyte-derived Dendritic cells (DCs) have successfully been employed to induce immune responses against tumor-associated antigens in patients with various cancer entities. However, objective clinical responses have only been achieved in a minority
Autor:
Herbert Schwarz, Lip Kun Tan, Joshua Tay, Liam Pock Ho, Robert John Walsh, Lingzhi Wang, Chwee Ming Lim, Madelaine Niam, Yvonne Ang, John E. Connolly, Marieta Chan, Bhushan Dharmadhikari, Ross A. Soo, Najwa Binte Said Nasir Talib, Reina Sng, Li Yating, Melissa Yan Ling Soh, Mickey Koh, Wan Qin Chong, Liang Piu Koh, Emily Nickles, Veonice Bijin Au, Boon Cher Goh, Yen Hoon Luah, Yiqing Huang, Yugarajah Asokumaran, Michelle Poon, Nivashini Kaliaperumal, Kwok Seng Loh
Publikováno v:
Cancer Immunology, Immunotherapy. 71:1531-1543
Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC), and provides a target for a dendritic cell (DC) vaccine. CD137 ligand (CD137L) expressed on antigen presenting cells, costimulates CD137-expressing T cells, and reverse CD137
Autor:
Tetsunari Oyama, Hideyuki Takahashi, Shota Ida, Yurino Nagata, Kei Masuda, Ikko Mito, Hideki Sezutsu, Toshiyuki Matsuyama, Masato Shino, Kazuaki Chikamatsu, Shigeki Takeda, Miho Uchida, Ken-Ichiro Tatematsu, Kanae Yamada, Hiroe Tada
Publikováno v:
Cancer Immunology, Immunotherapy. 71:851-863
Cancer immunotherapy using immune checkpoint inhibitors (ICIs) has been recognized as a novel therapeutic option for head and neck squamous cell carcinoma (HNSCC). However, only approximately 20-30% of patients with recurrent/metastatic (R/M) HNSCC b
Autor:
Aiko Murai, Tomohide Tsukahara, Yoshihiko Hirohashi, Takayuki Kanaseki, Takashige Abe, Terufumi Kubo, Shinichi Hashimoto, Kanta Hori, Haruka Miyata, Junko Yanagawa, Serina Tokita, Shuhei Yamada, Nobuo Shinohara, Toshihiko Torigoe
Publikováno v:
Cancer Immunology, Immunotherapy. 71:795-806
Recent studies have revealed that treatment-resistant cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) can be targeted by cytotoxic T lymphocytes (CTLs). CTLs recognize antigenic peptides derived from tumor-associated antigens; thus, the
Autor:
Akihiro Tsuboi, Haruo Sugiyama, Shinji Sogo, Naoki Hosen, Kanako Imafuku, Kana Hasegawa, Sumiyuki Nishida, Soyoko Morimoto, Keiko Udaka, Kazuki Isokawa, Fumihiro Fujiki, Jun Nakata, Yusuke Oji, Hiroko Nakajima, Yoshiko Hashii, Hiromu Hayashibara, Yoshihiro Oka
Publikováno v:
Cancer Immunology, Immunotherapy. 70:3323-3335
Helper T lymphocytes (HTLs) play a central role in cancer immunity because they can not only help the induction and proliferation of cytotoxic T lymphocytes (CTLs) but also their differentiation into cytotoxic CD4+ T cells and directly kill the targe
Autor:
Cham Jung, Rachelle Tibbetts, Tania Porras-Corredor, Sakunthala Muthugounder, Meng-Hua Lee, Shahab Asgharzadeh, Kee Kiat Yeo, Michael A. Sheard
Publikováno v:
Cancer Immunology, Immunotherapy. 71:153-164
Neuroblastoma (NBL) accounts for a disproportionate number of deaths among childhood malignancies despite intensive multimodal therapy that includes antibody targeting disialoganglioside GD2, a NBL antigen. Unfortunately, resistance to anti-GD2 immun
Autor:
Nora Berois, Teresa Freire, Ernesto Rodríguez, Gabriel Morón, Edgardo Berriel, Gabriel Fernández-Graña, Martina Crispo, Carolina Chiale, Eduardo Osinaga
Publikováno v:
Cancer Immunology, Immunotherapy. 70:3617-3627
Echinococcus granulosus is a cestode parasite which causes cystic echinococcosis disease. Previously we observed that vaccination with E. granulosus antigens from human hydatid cyst fluid (HCF) significantly inhibits colon cancer growth. In the prese
Autor:
Hideo Yagita, Linan Wang, Eiichi Sato, Yoshito Itoh, Tetsuya Okayama, Shinichi Kageyama, Takeshi Ishikawa, Satoshi Kokura, Hiroshi Shiku, Yoshihiro Miyahara
Publikováno v:
Cancer Immunology, Immunotherapy. 70:3081-3091
The nanoparticle complex of cholesteryl pullulan (CHP) and NY-ESO-1 antigen protein (CHP-NY-ESO-1) presents multiple epitope peptides to MHC class I and II pathways, leading to CD8+ and CD4+ T cell responses. Poly-ICLC is a synthetic, double-stranded
Autor:
Keishi Adachi, Shunsuke Goto, Masatoshi Eto, Yukimi Sakoda, Yoshitaka Sekido, Seiji Yano, Koji Tamada
Publikováno v:
Cancer Immunology, Immunotherapy. 70:2503-2515
Chimeric antigen receptor (CAR)-T cell therapy has impressive efficacy in hematological malignancies, but its application in solid tumors remains a challenge. Multiple hurdles associated with the biological and immunological features of solid tumors