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Autor:
Jan Budczies, Cornelius F. Waller, Amanda Tufman, Martina Kirchner, Torsten Goldmann, Albrecht Stenzinger, Peter Schirmacher, Petros Christopoulos, Michael Meister, Mark Kriegsmann, Michael Thomas, Martin Reck, Solange Peters, Klaus Kluck, Hauke Winter, Julia Glade, Daniel Kazdal, Stefan Fröhling, Michael Allgäuer, Thomas Muley, Felix J.F. Herth, CP Heußel, Martin Wermke
Publikováno v:
Cancer Immunology, Immunotherapy
Introduction The advent of immune checkpoint blockade (ICB) has led to significantly improved disease outcome in lung adenocarcinoma (ADC), but response of ALK/EGFR-positive tumors to immune therapy is limited. The underlying immune biology is incomp
Autor:
Weibin Hou, Jian Huang, Kun Xia, Meihua Yang, Meng Yang, Junyu Chen, Bo Wang, Tianxin Lin, Wenlong Zhong, Bingkun Zhou, Xiaofei Wang, Hao Yu
Publikováno v:
Cancer Immunology, Immunotherapy. 70:2657-2668
The expression status of programmed cell death-ligand 1/programmed cell death 1 (PD-L1/PD-1) and the infiltration of CD8+ T cells in tumor tissues are considered to be related to immunotherapy efficacy and patient prognosis. The purpose of this study
Autor:
Pedro Rocha, Dzifa Y. Douse, Lixia Diao, Humam Kadara, Jianjun Zhang, Debora A. Ledesma, Jose Luis Solorzano, John V. Heymach, Ruth Salazar, Luisa M. Solis, Neda Kalhor, Barbara Mino, J. Jack Lee, Don L. Gibbons, Cesar A. Moran, David C. Rice, Carmen Behrens, Pamela Villalobos, Ara A. Vaporciyan, Jiexin Zhang, Hitoshi Dejima, Annikka Weissferdt, Kyle G. Mitchell, Tina Cascone, Edwin Parra-Cuentas, Boris Sepesi, Xiuning Le, Ignacio I. Wistuba
Publikováno v:
Cancer Immunology, Immunotherapy
Introduction CD73 is a membrane-bound enzyme crucial in adenosine generation. The adenosinergic pathway plays a critical role in immunosuppression and in anti-tumor effects of immune checkpoint inhibitors (ICI). Here, we interrogated CD73 expression
Autor:
Yingying Wang, Junping Shi, Hongyuan Zhou, Ti Zhang, Yan Ke, QiangLi, Wei Zhang, Bo Yang, Zewu Zhang, Zhiqiang Han, Tianqiang Song, Guanghao Li, Guangtai Cao
Publikováno v:
Cancer Immunology, Immunotherapy. 70:1001-1014
Chemotherapy is a standard regimen for advanced or relapsed biliary tract cancer (BTC) with a 5-year overall survival (OS) rate of approximately 5% and a median OS of less than a year. Targeted therapies and immunotherapy aimed at providing more pers
Publikováno v:
Cancer Immunol Immunother
Loss of human leukocyte antigen (HLA) class 1 expression is a mechanism of tumor immune escape and may contribute to resistance to immunotherapy. Patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors can have disc
Autor:
Tetsuro Sasada, Akihito Hashizume, Ryosuke Jikuya, Kentaro Muraoka, Takeshi Kishida, Tomoyuki Yokose, Masato Yasui, Masahiko Sakaguchi, Yohei Miyagi, Yoshiyasu Nakamura, Susumu Umemoto, Masaki Kawai, Tomoyuki Tatenuma, Nobuhiko Mizuno, Mitsuyo Yoshihara
Publikováno v:
Cancer Immunology, Immunotherapy. 69:2041-2051
Recently, the effectiveness of anti-programmed death 1 (PD-1) antibody therapy in the treatment of renal cell carcinoma (RCC) has been established. Nevertheless, efficacy has been reported to be limited to only 10–30% of patients. To develop more e
Autor:
Giorgio Cattoretti, Lukas Marcelis, Thomas Tousseyn, Daan Dierickx, Anne-Marie Delsupehe, Pauline Biesemans, Gregor Verhoef, Francesca Maria Bosisio, Olivier Gheysens, Xavier Sagaert, Peter Vandenberghe, Koen Debackere, Julio Finalet Ferreiro, Asier Antoranz
Publikováno v:
Cancer Immunology, Immunotherapy. 69:1751-1766
Primary central nervous system lymphoma (PCNSL) is a rare type of non-Hodgkin lymphoma with an aggressive clinical course. To investigate the potential of immune-checkpoint therapy, we retrospectively studied the tumor microenvironment (TME) using hi
Autor:
Einar Gudlaugsson, Dordi Lea, Kjetil Søreide, Martin M. Watson, Hanne R. Hagland, Ivar Skaland
Publikováno v:
Cancer Immunology, Immunotherapy
Introduction Microsatellite instability (MSI) predict response to anti-PD1 immunotherapy in colorectal cancer (CRC). CRCs with MSI have higher infiltration of immune cells related to a better survival. Elevated Microsatellite Alterations at Tetranucl
Autor:
Hyung Ho Kim, Yujun Park, Sang Hoon Ahn, Woo Ho Kim, Jiwon Koh, Hye Seung Lee, Yoonjin Kwak, Do Joong Park
Publikováno v:
Cancer Immunology, Immunotherapy. 68:1779-1790
Human leukocyte antigen class I (HLA I) molecules composed of alpha (heavy) chain, including HLA-A, -B, or -C encoded by HLA genes, and beta-2-microglobulin (β2M) are membrane proteins on all nucleated cells that display peptide antigens for recogni
Autor:
Tian Li, Yifan Zhang, Monika Ehnman, Asle C. Hesla, Panagiotis Tsagozis, Felix Haglund, Nicholas P. Tobin, Martin Augsten, Jonas Bergh
Publikováno v:
Cancer Immunology, Immunotherapy
Background Immune cells can regulate disease progression and response to treatment in multiple tumor types, but their activities in human soft tissue sarcoma are poorly characterized. Methods Marker-defined immune cell subsets were characterized from