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Autor:
Pedro Rocha, Dzifa Y. Douse, Lixia Diao, Humam Kadara, Jianjun Zhang, Debora A. Ledesma, Jose Luis Solorzano, John V. Heymach, Ruth Salazar, Luisa M. Solis, Neda Kalhor, Barbara Mino, J. Jack Lee, Don L. Gibbons, Cesar A. Moran, David C. Rice, Carmen Behrens, Pamela Villalobos, Ara A. Vaporciyan, Jiexin Zhang, Hitoshi Dejima, Annikka Weissferdt, Kyle G. Mitchell, Tina Cascone, Edwin Parra-Cuentas, Boris Sepesi, Xiuning Le, Ignacio I. Wistuba
Publikováno v:
Cancer Immunology, Immunotherapy
Introduction CD73 is a membrane-bound enzyme crucial in adenosine generation. The adenosinergic pathway plays a critical role in immunosuppression and in anti-tumor effects of immune checkpoint inhibitors (ICI). Here, we interrogated CD73 expression
Autor:
Robert Geraghty, Aoife Maguire, Cara Dunne, Kieran Sheahan, Petra Martin, David Fennelly, Miriam Tosetto, James J. Phelan, Elizabeth J. Ryan, Jacintha O'Sullivan, Adriana J. Michielsen, Sinead Noonan, Margaret R. Dunne
Publikováno v:
Cancer Immunology, Immunotherapy
HLA-DR, an MHC class II molecule that mediates antigen presentation, is a favourable prognostic indicator in colorectal cancer (CRC). However, the dynamics and location of HLA-DR expression during CRC development are unclear. We aimed to define HLA-D
Publikováno v:
Cancer Immunology, Immunotherapy. 69:69-79
Colorectal cancer (CRC) is a leading cause of cancer-related death, partly due to a lack of reliable biomarkers for early diagnosis. To improve the outcome of CRC, it is critical to provide diagnosis at an early stage using promising sensitive/specif
Autor:
Masoud Sotoudeh, Ramin Shakeri, Mahmood Naderi, Sanford M. Dawsey, Naser Ahmadbeigi, Bahareh Sharififard
Publikováno v:
Cancer Immunol Immunother
BACKGROUND. Despite the promise of immunotherapy for gastric adenocarcinoma, choices for the selection of effective antigenic targets are very limited. Previously published data and our own in-house computational analysis have suggested that ANTXR1 i
Publikováno v:
Cancer Immunology, Immunotherapy. 68:443-454
Adenocarcinoma of the ampulla of Vater (AOV) is classified into intestinal type (IT) and pancreatobiliary type (PB); however, the immunological properties of these subtypes remain to be characterized. Here, we evaluated the clinical implications of P
Autor:
Tanios Bekaii-Saab, Jon P. Walker, Walter J. Coyle, Mark Bloomston, Gregory B. Lesinski, Lawrence A. Shirley, Christopher L. Marsh, Daniel Sanchez, Estuardo Aguilar-Cordova, Andrea G. Manzanera, Howard Marx, Vincent Chung, Laura K. Aguilar, Benjamin Swanson
Publikováno v:
Cancer Immunology, Immunotherapy. 64:727-736
While surgical resection of pancreatic adenocarcinoma provides the only chance of cure, long-term survival remains poor. Immunotherapy may improve outcomes, especially as adjuvant to local therapies. Gene-mediated cytotoxic immunotherapy (GMCI) gener
Autor:
Mohammad-Hossein Ghahremani, Roya Ghods, Ahmad-Reza Mahmoudi, Parvin Pasalar, Mahmood Jeddi-Tehrani, Zahra Madjd, Maryam Abolhasani, Maryam Darzi, Sanaz Tavasoli, Mojgan Asgari, Amir-Hassan Zarnani
Publikováno v:
Cancer Immunology, Immunotherapy. 63:1319-1327
The scarcity of effective therapeutic approaches for prostate cancer (PCa) has encouraged steadily growing interest for the identification of novel antigenic targets. Placenta-specific 1 (PLAC1) is a novel cancer–testis antigen with reported ectopi
Autor:
Bengt Gustavsson, Marianne Quiding-Järbrink, Veronica Langenes, Lars Börjesson, Helena Svensson, Mats Bemark, Åsa Sjöling
Publikováno v:
Cancer Immunology, Immunotherapy. 62:1687-1695
Recruitment of immune cells to tumors is a complex process crucial for both inflammation-driven tumor progression and specific anti-tumor cytotoxicity. Chemokines control the directed migration of immune cells, and their actions are partly controlled
Autor:
Zhijia Liu, Chaojun Song, Yongming Li, Rongrong Liu, Qi Li, Jun Chen, Lihua Chen, Yun Dong, Jian Zhang, Jiuyu Gong, Boquan Jin
Publikováno v:
Cancer Immunology, Immunotherapy. 61:855-864
Calreticulin (CRT) is an endoplasmic reticulum luminal Ca(2+)-binding chaperone protein. By immunizing mice with recombinant fragment (rCRT/39-272), six clones of monoclonal antibodies (mAbs) were generated and characterized. Based on these mAbs, a m
Autor:
Francisco J. Vizoso, Luis O. González, José M. González, Alina Aguirre, Aurelio Suárez, Jesús M. Fernández, Safwan Escaff, Salomé González-Reyes
Publikováno v:
Cancer Immunology, Immunotherapy. 60:217-226
Toll-like receptors (TLRs) have garnered an extraordinary amount of interest in cancer research due to their role in tumor progression. By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, wh