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Publikováno v:
Cancer Gene Therapy. 27:399-411
Many efforts have been taken to develop molecule target for cancer therapy. 14-3-3zeta protein has emerged as a critical regulator of diverse cellular pathways in multiple cancers. Furthermore, 14-3-3zeta expression was elevated and a predictor of po
Publikováno v:
Cancer Gene Therapy. 25:129-140
To gain insight into the molecular pathogenesis of patients with mantle cell lymphoma (MCL), next-generation whole-exome sequencing of 16 MCL patients was performed. We identified recurrent mutations in genes that are well known to be functionally re
Publikováno v:
Cancer Gene Therapy. 18:444-449
This phase II clinical trial compared the efficacy and safety of two types of treatment in patients with non-small-cell lung cancer (NSCLC) who had previously been treated with chemotherapy. Patients diagnosed with NSCLC (with either measurable or ev
Autor:
Ann Cahill, Mario Sznol, Casey Cunningham, Neil Senzer, Jennifer Cramm, John Nemunaitis, Craig Litz, Joseph A. Kuhn, Robert Cavagnolo, Caroline Clairmont
Publikováno v:
Cancer Gene Therapy. 10:737-744
We performed a pilot trial in refractory cancer patients to investigate the feasibility of intratumoral injection of TAPET-CD, an attenuated Salmonella bacterium expressing the E. coli cytosine deaminase gene. A total of three patients received three
Autor:
Britta Randlev, Brenda Gibson, Dawn Rich, Alex W. Tong, Beverly Sands, Angela Blackburn, Casey Cunningham, Leonard Post, A. Scott Paulson, Scott Freeman, George J. Netto, John Nemunaitis
Publikováno v:
Cancer Gene Therapy. 10:341-352
ONYX-015 is an adenovirus that selectively replicates in p53 dysfunctional or mutated malignant cells. We performed a pilot trial to determine the safety and feasibility of treatment with ONYX-015 delivered intravenously in patients with advanced mal
Autor:
T. Whiteside, Alok A. Khorana, S. Phillippe, Bruce Acres, Karen Rosell, K. Kendra, M. Ross, Diana Marquis, Joseph D. Rosenblatt, Deepak M. Sahasrabudhe, Philippe Slos, Thomas J Evans, Patrick Squiban, M. Ladrigan
Publikováno v:
Cancer Gene Therapy. 10:251-259
Interferon-gamma (IFN-gamma) has been shown to upregulate MHC class I and II expression, and to promote generation of specific antitumor immune responses. We hypothesized that intratumoral administration of an IFN-gamma gene transfer vector facilitat