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Autor:
Michael J. Schell, Michael Nebozhyn, W. Jack Pledger, Jiannong Li, Jamie K. Teer, Mingli Yang, Timothy J. Yeatman, Andrey Loboda
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 28:1141-1152
Background: EGFR is a major therapeutic target for colorectal cancer. Currently, extended RAS/RAF testing identifies only nonresponders to EGFR inhibitors (EGFRi). We aimed to develop a mutation signature that further refines drug-sensitive subpopula
Autor:
Dana M. van Bemmel, Dorothy K. Hatsukami, Connie S. Sosnoff, Cindy M. Chang, Brian L. Rostron, Arseima Y. Del Valle-Pinero, Yuesong Wang, Maciej L. Goniewicz, Heather L. Kimmel, Bridget K. Ambrose, Kevin P. Conway, Joanne T. Chang, Benjamin C. Blount, Catherine G. Corey, Stephen Arnstein, Andrew Hyland, Kathryn C Edwards, Kristie Taylor, Lanqing Wang, Maocheng Yang, Mark J. Travers, Nicolette Borek
Publikováno v:
Cancer Epidemiol Biomarkers Prev
Background: Given the diverse cigar market and limited data on biomarker patterns by cigar type, we compared biomarkers of nicotine and tobacco toxicants among cigar smokers and other groups. Methods: Using Wave 1 urinary biomarker data from 5,604 ad
Autor:
John Karanicolas, Keerthana Gnanapradeepan, Jessica C. Leung, Maureen E. Murphy, Lei Ke, Tim Barnoud
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 29:PR08-PR08
The p53 tumor suppressor gene plays a central role in human cancer. In addition to mutation, there are genetic coding region variants of p53 that exist in different ethnic groups. In some cases, these variants have incomplete or impaired function and
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 24:1416-1418
In metastatic colorectal cancer, KRAS and NRAS genotyping is mandatory before prescription of panitumumab or cetuximab. In order to perform such molecular tests, the French National Cancer Institute has set up a nationwide network of molecular center
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 20:1524-1536
Background: This multicenter, observational study was conducted in three European countries (Germany, Switzerland, and the United Kingdom) to determine the exposure of adult cigarette smokers and nonsmokers to selected cigarette smoke constituents: 1
Autor:
Natalie Weisensel, Linda B. von Weymarn, Sharon E. Murphy, Katherine M. Wickham, Elizabeth A. Thompson, Jeannette Zinggeler Berg, Dorothy K. Hatsukami
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 19:1423-1431
Background: Tobacco exposure is routinely assessed by quantifying nicotine metabolites in plasma or urine. On average, 80% of nicotine undergoes C-oxidation to cotinine. However, interindividual variation in nicotine glucuronidation is substantial, a
Autor:
David S. Millington, Ivan Spasojevic, Jeffrey R. Marks, Adviye A. Tolun, Sarah P. Young, Richard T. DiGiulio, Karel Base, P. Kelly Marcom, Frances Wang, Gabriel Mixon, Dora Il'yasova
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 19:1506-1510
Background: We used doxorubicin-based chemotherapy as a clinical model of oxidative assault in humans. Methods: The study recruited newly diagnosed breast cancer patients (n = 23). Urine samples were collected immediately before (T0) and at 1 hour (T
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 19:1160-1166
Background: We sought to determine the optimal plasma and urine nicotine metabolites, alone or in combination, to estimate the systemic dose of nicotine after low-level exposure. Methods: We dosed 36 nonsmokers with 100, 200, or 400 μg p.o. of deute
Autor:
Jagadeesan Nair, Paiboon Sitthithaworn, Puangrat Yongvanit, Somchai Pinlaor, Helmut Bartsch, Somkid Dechakhamphu
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 19:310-318
Chronic infection by the liver fluke Opisthorchis viverrini is a strong risk factor for cholangiocarcinoma. To clarify the involvement of oxidative stress and lipid peroxidation–derived DNA damage, etheno (ϵ)-DNA adducts (ϵdA, ϵdC) in WBC and pl
Autor:
Jonathan M. Samet, Patrick N. Breysse, Heather Wipfli, Sungroul Kim, Francesca Dominici, Erika Avila-Tang, Ana Navas-Acien, Georgiana Onicescu
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 18:3407-3414
The main purpose of this study was to identify and evaluate determinants of hair nicotine concentrations in nonsmoking women and children exposed to secondhand tobacco smoke at home. Hair samples were collected from nonsmoking women (n = 852) and fro