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Autor:
Natalie Weisensel, Linda B. von Weymarn, Sharon E. Murphy, Katherine M. Wickham, Elizabeth A. Thompson, Jeannette Zinggeler Berg, Dorothy K. Hatsukami
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 19:1423-1431
Background: Tobacco exposure is routinely assessed by quantifying nicotine metabolites in plasma or urine. On average, 80% of nicotine undergoes C-oxidation to cotinine. However, interindividual variation in nicotine glucuronidation is substantial, a
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 19:1160-1166
Background: We sought to determine the optimal plasma and urine nicotine metabolites, alone or in combination, to estimate the systemic dose of nicotine after low-level exposure. Methods: We dosed 36 nonsmokers with 100, 200, or 400 μg p.o. of deute
Autor:
Amal A. Alotaibi
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 23:C38-C38
Survivin is a novel member of the IAP family of proteins with a potential dual role in apoptosis inhibition and regulation of mitosis. In addition, survivin is implicated in the regulation of the mitotic spindle checkpoint and the promotion of angiog
Autor:
Weiqiang Zhao, Mark A. Socinski, Sherri L. Starrett, Miguel A. Villalona-Calero, Mitch A. Phelps, Gregory A. Otterson, William J. Hicks, Thomas E. Stinchcombe, Larry J. Schaaf, James S. Blachly
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 21:A43-A43
Context: Focused evaluation of the efficacy and pharmacokinetics of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), and the potential influence of pharmacogenetics and tumor genetics, has not been previously performed in Af