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Autor:
Olivier A. Bernard, Wojciech Rosikiewicz, Rita Shaknovich, Michael R. Green, María Fernández, Iannis Aifantis, Enguerran Mouly, Miguel Torres-Martin, Alan H. Shih, Saber Tadros, Ross L. Levine, Véronique Della-Valle, Ari Melnick, Luisa Cimmino, Matt Durant, Pilar M. Dominguez, Nathalie Droin, Patrycja Pawlikowska, Said Aoufouchi, Parveen Kumar, Matt Teater, Wayne Tam, Wendy Béguelin, Marine Armand, Martín A. Rivas, Hussein Ghamlouch, Giorgio Inghirami, Mark A. Rubin, Lorena Fontan, Olivier Elemento, Ashley S. Doane, Samaneh Motanagh, Maria E. Figueroa, Sheng Li
Publikováno v:
Cancer discovery. 8(12)
TET2 somatic mutations occur in ∼10% of diffuse large B-cell lymphomas (DLBCL) but are of unknown significance. Herein, we show that TET2 is required for the humoral immune response and is a DLBCL tumor suppressor. TET2 loss of function disrupts tr