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Autor:
Carolyn Shembrey, Kristin K. Brown, Izabela Todorovski, Zheng Fan, Thomas Abrehart, Giovanna Pomilio, Andrew H. Wei, Jennifer R. Devlin, Emily Gruber, Stefan Bjelosevic, Stephin J. Vervoort, Ricky W. Johnstone, Andrea Newbold, Simon J. Hogg, Lev Kats, Gareth P. Gregory
Publikováno v:
Cancer discovery. 11(6)
Internal tandem duplication of the FMS-like tyrosine kinase 3 gene (FLT3-ITD) occurs in 30% of all acute myeloid leukemias (AML). Limited clinical efficacy of FLT3 inhibitors highlights the need for alternative therapeutic modalities in this subset o