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Autor:
Ivan Babic, Harley I. Kornblum, Harry V. Vinters, Fuyuhiko Tamanoi, Steven J. Bensinger, Huijun Yang, David Akhavan, Alex Nourian, Paul S. Mischel, Alexandra L. Pourzia, Takashi Sasayama, C. David James, Julie Dang, Genaro R. Villa, Webster K. Cavenee, Kazuhiro Tanaka, Ali Nael, William H. Yong, David Nathanson, Mitchell Flagg, Timothy F. Cloughesy, Kevin J. Williams
Publikováno v:
Cancer Discovery. 3:534-547
Acquired resistance to tyrosine kinase inhibitors (TKI) represents a major challenge for personalized cancer therapy. Multiple genetic mechanisms of acquired TKI resistance have been identified in several types of human cancer. However, the possibili
Autor:
John Sinclair, James Larkin, Andrew J. Hayes, Berta Sanchez-Laorden, Paul Lorigan, Martin Gore, Richard Marais, Caroline J. Springer, Samra Turajlic, Dan Niculescu-Duvaz, Amaya Viros, Maria Romina Girotti, Malin Pedersen, Alfonso Zambon, Claus Jørgensen
Publikováno v:
Cancer Discovery. 3:158-167
We generated cell lines resistant to BRAF inhibitors and show that the EGF receptor (EGFR)–SRC family kinase (SFK)–STAT3 signaling pathway was upregulated in these cells. In addition to driving proliferation of resistant cells, this pathway also
Autor:
Casey G. Langdon, Ashok K. Chakraborty, Antonella Bacchiocchi, David F. Stern, Marcus Bosenberg, Andrew B. Koo, James T. Platt, Jonathan W. Haskins, Matthew A. Held, Tisheeka Graham-Steed, Zongzhi Liu
Publikováno v:
Cancer Discovery. 3:52-67
Resistance and partial responses to targeted monotherapy are major obstacles in cancer treatment. Systematic approaches to identify efficacious drug combinations for cancer are not well established, especially in the context of genotype. To address t
Autor:
Jing Wang, Lauren Averett Byers
Publikováno v:
Cancer Discovery. 3:1333-1335
Small cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with high mortality. We used a systematic drug repositioning bioinformatics approach querying a large compendium of gene expression profiles to identify candidate U.