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pro vyhledávání: ''
Autor:
Kei-ichiro Arimoto, Leo J.Y. Kim, Balázs Győrffy, Klaus-Peter Knobeloch, Dong-Er Zhang, Hua Cheng, Christoph Burkart, Xiang-Dong Fu, Jeremy N. Rich, Hu Cang, Jun-Bao Fan, Yu Zhou, Hui-Zhong Xu, Ming Yan, Sayuri Miyauchi, Dan Liu
Publikováno v:
Cancer Discov
Type I interferons (IFN), which activate many IFN-stimulated genes (ISG), are known to regulate tumorigenesis. However, little is known regarding how various ISGs coordinate with one another in developing antitumor effects. Here, we report that the I
Autor:
Beow Y. Yeap, David T. Myers, Taronish D. Dubash, Michael S. Lawrence, Alice T. Shaw, Nicholas J. Dyson, Sarah Phat, Robert Morris, Anna F. Farago, David A. Barbie, J. Paul Marcoux, Shyamala Maheswaran, Benjamin J. Drapkin, Elizabeth Kennedy, Jun Zhong, Yin P Hung, Rebecca S. Heist, Subba R. Digumarthy, Lecia V. Sequist, Aaron N. Hata, Marina Kem, Mari Mino-Kenudson, Daniel A. Haber, Marcello Stanzione, Deepa Rangachari
Publikováno v:
Cancer Discovery. 9:1372-1387
Small-cell lung cancer (SCLC) is an aggressive malignancy in which inhibitors of PARP have modest single-agent activity. We performed a phase I/II trial of combination olaparib tablets and temozolomide (OT) in patients with previously treated SCLC. W
Autor:
Francisco Vega, Kristen L Jones, Sara N. Morrow, Michael T. Hemann, Yunpeng Liu, Amanda L. Christie, Olivia Plana, Quang-Dé Nguyen, Jon C. Aster, Jeffrey W. Craig, Alex K. Shalek, Elizabeth A. Morgan, Alexandria Van Scoyk, Huiyun Liu, Kellie E. Kolb, David M. Weinstock, Kay Shigemori, Kristopher A. Sarosiek, Chen Lossos, Cameron Fraser, Kristen E. Stevenson, Sanjay M. Prakadan, Christian P. Pallasch, Rebecca Modiste
Publikováno v:
PMC
The extraordinary activity of high-dose cyclophosphamide against some high-grade lymphomas was described nearly 60 years ago. Here we address mechanisms that mediate cyclophosphamide activity in bona fide human double-hit lymphoma. We show that antib
Autor:
Marina Kem, Sotirios Lakis, Maria Gomez-Caraballo, Roopika Menon, Peter Igo, Ruben Dries, Mari Mino-Kenudson, Reinhard Büttner, Shyamala Maheswaran, Daniel A. Haber, Kwok-Kin Wong, David T. Myers, Camilla L. Christensen, Joseph A. LiCausi, Sarah Phat, Tilak K. Sundaresan, Jun Zhong, Benjamin J. Drapkin, Lecia V. Sequist, Stefan A. Haas, Nicholas J. Dyson, Anna F. Farago, Julie George, Kandarp Jani, Aaron N. Hata, Nima Abedpour, Mehmet Toner, Alice T. Shaw, Martin Peifer, Rebecca S. Heist, Roman K. Thomas, Mehlika Hazar-Rethinam, Roxana Azimi
Publikováno v:
Cancer Discovery
Small cell lung cancer (SCLC) patient-derived xenografts (PDX) can be generated from biopsies or circulating tumor cells (CTC), though scarcity of tissue and low efficiency of tumor growth have previously limited these approaches. Applying an establi
Autor:
Natalia Mitin, Judith Campisi, Alexis Valdovinos, Norman E. Sharpless, Jianhui Chang, Boshi Wang, Hyman B. Muss, Shani Alston, Kristin Koenig, Allison M. Deal, Brian K. Kennedy, Alain de Bruin, Sumner Kilmarx, Fatouma Alimirah, Catherine H. Le, Simon Melov, Monique N. O’Leary, Lijian Shao, Emmeline C. Academia, Daohong Zhou, Su Liu, Marco Demaria
Publikováno v:
Demaria, M; O’Leary, MN; Chang, J; Shao, L; Liu, S; Alimirah, F; et al.(2017). Cellular senescence promotes adverse effects of chemotherapy and cancer relapse. Cancer Discovery, 7(2), 165-176. doi: 10.1158/2159-8290.CD-16-0241. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/54h8z0j1
Cancer discovery, vol 7, iss 2
Cancer discovery, 7(2), 165-176. AMER ASSOC CANCER RESEARCH
Cancer discovery, vol 7, iss 2
Cancer discovery, 7(2), 165-176. AMER ASSOC CANCER RESEARCH
Cellular senescence suppresses cancer by irreversibly arresting cell proliferation. Senescent cells acquire a proinflammatory senescence-associated secretory phenotype. Many genotoxic chemotherapies target proliferating cells nonspecifically, often w
Autor:
Aram F. Hezel, Nabeel Bardeesy, Cyril H. Benes, Jia-Chi Yeo, James T. Webber, Kevan M. Shokat, Travis Sullivan, Benjamin P. Kleinstiver, Roger L. Jenkins, Ultan McDermott, Yusuke Mizukami, Leah J. Damon, Regina K. Egan, Lei Shi, Supriya K. Saha, J. Keith Joung, John D. Gordan, Patricia Greninger, Rebecca S. Levin, Andrew S. Liss, Yasutaka Kato, Andrew X. Zhu, Kimberly M. Rieger-Christ, Mortada S. Najem, Lipika Goyal, Cristina R. Ferrone, Phuong Vu, Mathew J. Garnett
Publikováno v:
Cancer discovery, vol 6, iss 7
Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver bile duct malignancy exhibiting frequent isocitrate dehydrogenase (IDH1/IDH2) mutations. Through a high-throughput drug screen of a large panel of cancer cell lines, including 17 biliary tr
Autor:
Ludovic Martinet, Mark J. Smyth, Deepak Mittal, Michele W.L. Teng, Günter Bernhardt, Marco Colonna, John J. Miles, Engin Gürlevik, Lucas Ferrari de Andrade, Stacey Allen, Viviana P. Lutzky, Kazuyoshi Takeda, Stephen J. Blake, Amelia Roman Aguilera, Florian Kühnel, Michelle C.R. Yong, Kimberley Stannard, Jing Liu
Publikováno v:
Cancer Discovery. 6:446-459
CD96 has recently been shown as a negative regulator of mouse natural killer (NK)–cell activity, with Cd96−/− mice displaying hyperresponsive NK cells upon immune challenge. In this study, we have demonstrated that blocking CD96 with a monoclon
Autor:
Ilaria Conti, Sheng-Bin Peng, James J. Starling, Igor Mochalkin, Henry James Robert, Sean Buchanan, Robert D. Van Horn, Lysiane Huber, Gregory D. Plowman, Swee Seong Wong, Youyan Zhang, Vipin Yadav, Yong Gang Yue, Shih-Hsun Chen, Tinggui Yin
Publikováno v:
Cancer Discovery. 6:300-315
We have identified previously undiscovered BRAF in-frame deletions near the αC-helix region of the kinase domain in pancreatic, lung, ovarian, and thyroid cancers. These deletions are mutually exclusive with KRAS mutations and occur in 4.21% of KRAS
Autor:
Jaime L. Wolfe, Cynthia L. Sears, Shaoguang Wu, David L. Huso, Xinqun Wu, Drew M. Pardoll, Abby L. Geis, Hongni Fan, Franck Housseau
Publikováno v:
Cancer Discovery. 5:1098-1109
Many epithelial cancers are associated with chronic inflammation. However, the features of inflammation that are procarcinogenic are not fully understood. Regulatory T cells (Treg) typically restrain overt inflammatory responses and maintain intestin
Publikováno v:
Cancer Discovery. 5:410-423
Macroautophagy (autophagy hereafter) may promote survival and growth of spontaneous tumors, including melanoma. We utilized a genetically engineered mouse model of melanoma driven by oncogenic BrafV600E and deficiency in the Pten tumor suppressor gen