Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Hongxia Lin"'
Autor:
Nancy Chan, Jiuping Ji, Antoinette R. Tan, Janice M. Mehnert, Alice P. Chen, Jan H. Beumer, Mansi Shah, Joseph Aisner, Murugesan Gounder, Jyoti Malhotra, Rebecca A. Moss, Yong Lin, Brian F. Kiesel, Hongxia Lin, Mark N. Stein, Michael P. Kane
Publikováno v:
Cancer Chemother Pharmacol
Purpose Veliparib (V), an oral poly(ADP-ribose) polymerase (PARP) inhibitor, potentiates effects of alkylating agents and topoisomerase inhibitors in preclinical tumor models. We conducted a phase I trial of V with iv cyclophosphamide (C) and V plus
Autor:
Jyoti Malhotra, Eileen White, Daniella E Portal, Joseph Aisner, Hongxia Lin, Mark N. Stein, Rebecca A. Moss, Susan Goodin, Kristen Spencer, Laurence A Doyle, Amanda Kaveney, Darlene Gibbon, Janice M. Mehnert, Joseph R. Bertino, Antoinette R. Tan
Publikováno v:
Cancer Chemotherapy and Pharmacology. 84:899-907
Given the evidence that coordinate inhibition of AKT induces autophagy, we studied the combination of the AKT inhibitor, MK-2206 with hydroxychloroquine (HCQ) in patients with advanced solid tumors. Patients were treated with weekly MK-2206 (135 mg o