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New clinically relevant, orthotopic mouse models of human chondrosarcoma with spontaneous metastasis
Publikováno v:
Cancer Cell International
Cancer Cell International, Vol 10, Iss 1, p 20 (2010)
Cancer Cell International, Vol 10, Iss 1, p 20 (2010)
Background Chondrosarcoma responds poorly to adjuvant therapy and new, clinically relevant animal models are required to test targeted therapy. Methods Two human chondrosarcoma cell lines, JJ012 and FS090, were evaluated for proliferation, colony for
Publikováno v:
Cancer Cell International
Cancer Cell International, Vol 10, Iss 1, p 9 (2010)
Cancer Cell International, Vol 10, Iss 1, p 9 (2010)
The DNA enzyme Dz13, targeted against the oncogene c-Jun, is capable of inhibiting various model tumours in mice albeit in ectopic models of neoplasia. In previous studies using orthotopic models of disease, the inhibitory effects of Dz13 on secondar
Autor:
Peter F. M. Choong, Crispin R. Dass
Publikováno v:
Cancer Cell International. 6:17
Cationic (positively charged) liposomes have been tested in various gene therapy clinical trials for neoplastic and other diseases. They have demonstrated selectivity for tumour vascular endothelial cells raising hopes for both antiangiogenic and ant