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Autor:
Aleida Olivares, Patricia Casas-González, Marco Allán Pérez-Solis, Arturo Aguilar-Rojas, Guadalupe Maya-Núñez
Publikováno v:
Cancer Cell International
Through research carried out in the last 25 years about the breast cancer etiology, it has been possible to estimate that less than 10 % of patients who are diagnosed with the condition are carriers of some germline or somatic mutation. The clinical
Publikováno v:
Cancer Cell International
Background Autophagy can either be protective and confer survival to stressed cells, or it can contribute to cell death. The antimitotic drug 2-ethyl-3-O-sulpamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) is an in silico-designed 17-β-estradiol
Autor:
Hossein Ghasemzadeh Kolagar, Soheila Yadollah-Damavandi, Mohammad Amin Azizi, Mohammad Amin Javidi, Tina Parsa, Ehsan Jangholi, Yekta Parsa, Seyed Abbas Mirmalek, Reza Alizadeh-Navaei, Seyed Alireza Salimi-Tabatabaee
Publikováno v:
Cancer Cell International
Background Breast cancer is the most prevalent malignancies among the women that have a high mortality. Previous studies demonstrated that hypericin, a bioactive component of Hypericum perforatum have a cytotoxic effect on the malignant cell lines. H
Publikováno v:
Cancer Cell International
Background Suberoyl bis-hydroxamic acid (SBHA) is a histone deacetylase (HDAC) inhibitor and exerts anti-growth effects in several malignancies including breast cancer. Proteasome inhibitors such as Bortezomib and MG-132 constitute novel anticancer a
Autor:
Jiong Wu, Mengying Liu, Shuling Zhou, Yayun Chi, Lin Yuan, Bingqing Zhou, Naisi Huang, Sheng Huang
Publikováno v:
Cancer Cell International
Background Accumulating studies have focused on the oncogenic and tumor suppressive roles of the newly identified lncRNAs. A novel lncRNA BC040587 in 3q13.31 locus which exists frequent copy number alterations was found to be associated with poor sur
Autor:
Liu-Mei Shou, Meng Shen, Kai Chen, Meng-Dan Xu, Min Jiang, Meng-Yao Wu, Wei-Ming Duan, Xiao Wu, Wei Li, Juan Hou, Min Tao, Fei-Ran Gong, Xiaojie Bian, Qiaoming Zhi
Publikováno v:
Cancer Cell International
Purpose Despite new developments in cancer therapy, chemotherapy and radiotherapy remain the cornerstone of breast cancer treatment. Therefore, finding ways to reduce the toxicity and increase sensitivity is particularly important. Tumor necrosis fac
Publikováno v:
Cancer Cell International
Background The specific mechanism underlying the contribution of the Aldehyde dehydrogenase 1 (ALDH1) phenotype to metastatic behavior and early tumor relapse in breast cancer is currently unclear. Methods 147 randomly selected invasive ductal carcin
Publikováno v:
Cancer Cell International, Vol 8, Iss 1, p 12 (2008)
Cancer Cell International
Cancer Cell International
BackgroundBreast cancer is the most common cancer and cause of deaths in women around the world. Oncogene amplification usually occurs late in tumor progression and correlates well with aggressiveness of tumor. In fact the function of the S100A4 prot
Publikováno v:
Cancer Cell International
Background Increasing evidence suggest that ubiquitin-proteasome system (UPS) plays a key role in tumorigenesis. HERC4 is a recently identified ubiqutin ligase. However, the expression status and biological functions of HERC4 in cancers are not clear
Publikováno v:
Cancer Cell International
E-cadherin internalization facilitates dissolution of adherens junctions and promotes tumor cell epithelial-mesenchymal transition (EMT) and migration. Our previous results have shown that Arf6 exerts pro-migratory action in breast cancer cells after