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Publikováno v:
Cancer Cell
Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered fundamental regulators of tumorigenesis. However, the specific separation of functions that determine their different roles in cancer is still being unraveled. Both aPK
Autor:
Haojie Huang, Jacob J. Orme
Publikováno v:
Cancer cell
SUMMARY Despite the development of second-generation antiandrogens, acquired resistance to hormone therapy remains a major challenge in treating advanced prostate cancer. We find that cancer-associated fibroblasts (CAFs) can promote antiandrogen resi
Autor:
Anne Fassl, Piotr Sicinski
Publikováno v:
Cancer Cell. 37:265-267
Chemotherapy remains the main treatment option for patients with several tumor types. In this issue of Cancer Cell, Salvador-Barbero et al. demonstrate that treatment with CDK4/6 inhibitors after application of taxanes (or other chemotherapeutic comp
Publikováno v:
Cancer Cell. 35:347-367
Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor cells with the ability to proliferate without restraint, to invade through
Autor:
Sheeba Irshad, Paul Fields, Doraid Alrifai, Richard Davis, Yin Wu, Isaac Francos Quijorna, Anna Lorenc, Eva Bugallo-Blanco, Julie Nuo En Chan, Anne Rigg, Jennifer Vidler, Adrian Hayday, Aadil A. Khan, Julien de Naurois, Charlotte Moss, Sultan Abdul-Jawad, Pierre Vantourout, Louisa Mcdonald, Duncan R. McKenzie, Mieke Van Hemelrijck, Paul R. Barber, Irene del Molino del Barrio, Sophie Papa, Katharine Bailey, Deborah Enting, Beth Russell, Sophie Hazell, Sarah Gee, Tony Ng, Sarah Ryan, You Zhou, Anthony C. C. Coolen, Iva Zlatareva, Piers E.M. Patten, Adam Laing, Sophia N. Karagiannis, Miguel Muñoz-Ruiz, Luca Bau, Thomas Hayday, Yadanar Lwin, Shraddha Kamdar, Matthew Fish, Reuben Benjamin, Rozalyn Yorke, Aislinn Jennings, Katie J. Doores, Mayur Kumar, Thanussuyah Alaguthurai, Leticia Monin, Mark Rowley, James Spicer
Publikováno v:
Cancer Cell
Given the immune system's importance for cancer surveillance and treatment, we have investigated how it may be affected by SARS-CoV-2 infection of cancer patients. Across some heterogeneity in tumor type, stage, and treatment, virus-exposed solid can
Autor:
Davide Bedognetti
Publikováno v:
Cancer cell. 38(3)
Immune checkpoint blockade has limited activity in the large majority of hematologic malignancies. In this issue of Cancer Cell, Dufva et al. provide an immunologic portrait of these heterogenous diseases and identify key relationships between oncoge
Autor:
Fei Ma, Yuanyuan Zhang, Ting Hu, Yong Wang, Xiao Yu, Zemin Zhang, Tongyang Gong, Xueda Hu, Baolin Liu, Yahui Zhao, Xiaoying Sun, Xiuwen Guan, Hongnan Mo, Binghe Xu, Tianyi Qian, Qing Chang, Ranran Gao, Lijuan Niu, Hongyan Chen, Zhihua Liu
Publikováno v:
Cancer Cell. 39:1578-1593.e8
Summary In triple-negative breast cancer (TNBC), the benefit of combining chemotherapy with checkpoint inhibitors is still not very clear. We utilize single-cell RNA- and ATAC-sequencing to examine the immune cell dynamics in 22 patients with advance
Autor:
Shan Lin, Amy Saur Conway, Biniam Adane, Amanda Balboni Iniguez, Richard A. Young, Neekesh V. Dharia, Elizabeth Hwang, Francisca Vazquez, Filemon S. Dela Cruz, Diana Lu, Kimberly Stegmaier, Gabriela Alexe, John M. Krill-Burger, Caleb A. Lareau, Bo Kyung A. Seong, Jason N. Berman, Andrew L. Kung, Benjamin Tanenbaum, Monica Schenone, Martin J. Aryee, Denes Hnisz, Amanda L. Robichaud, Melissa Richardson, Linda Ross, Brian D. Crompton, Abraham S. Weintraub, Steven A. Carr, Sarah Wang
Publikováno v:
Cancer Cell
The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological role is less clear. Herein, we demonstrate that cohesin complexes containing STAG2 occupy enhancer and polycomb repressive complex (PRC2) marked regulatory regi
Autor:
Kelli M. Wilson, Akira Yuno, Brian Elenbaas, Jessica Kindrick, Carleen Klumpp-Thomas, Hirity Shimellis, Cody J. Peer, Javed Khan, Yilun Sun, Crystal McKnight, Astrid Zimmermann, Linda Sciuto, Mirit I. Aladjem, Sam Michael, Jun S. Wei, Lu Chen, William D. Figg, Yves Pommier, Jane B. Trepel, Jillian Varonin, Heike Dahmen, Zina Itkin, Sunmin Lee, Yang Zhang, Samantha Nichols, Xiaohu Zhang, Seth M. Steinberg, Erin S Beck, Christopher W. Schultz, Anish Thomas, Min-Jung Lee, Michele Ceribelli, Sehyun Kim, Janusz Puc, Vinodh N. Rajapakse, Parth Rakesh Desai, Nobuyuki Takahashi, Jameson Travers, Christophe E. Redon, Craig J. Thomas, Frank Zenke
Publikováno v:
Cancer Cell. 39:566-579.e7
Small cell neuroendocrine cancers (SCNCs) are recalcitrant cancers arising from diverse primary sites that lack effective treatments. Using chemical genetic screens, we identified inhibition of ataxia telangiectasia and rad3 related (ATR), the primar
Autor:
Kevan M. Shokat, William A. Weiss, William Clay Gustafson, Daphne A. Haas-Kogan, Joanna J. Phillips, Erin F. Simonds, Ozlem Aksoy, Geraldine Cayanan, Shirin Ilkhanizadeh, Robyn A. Wong, Qi-Wen Fan, Albert Truong, Masanori Okaniwa, Theodore Nicolaides, Chris J. Novotny
Publikováno v:
Cancer cell, vol 31, iss 3
Although signaling from phosphatidylinositol 3-kinase (PI3K) and AKT to mechanistic target of rapamycin (mTOR) is prominently dysregulated in high-grade glial brain tumors, blockade of PI3K or AKT minimally affects downstream mTOR activity in glioma.