Zobrazeno 1 - 5
of 5
pro vyhledávání: '"11"'
Autor:
Stanley J. Korsmeyer, Michael Certo, Victoria Del Gaizo Moore, Guo Wei, Mari Nishino, Scott A. Armstrong, Anthony Letai
Publikováno v:
Cancer Cell. 9:351-365
Summary We show that the antiapoptotic proteins BCL-2, BCL-XL, MCL-1, BFL-1, and BCL-w each bear a unique pattern of interaction with a panel of peptides derived from BH3 domains of BH3-only proteins. Cellular dependence on an antiapoptotic protein f
Autor:
Arletta Lozanski, Dasheng Wang, Joseph M. Flynn, Shruti Jha, Ching-Shih Chen, Sarah E. M. Herman, Jeffrey A. Jones, Paul A. Algate, David M. Lucas, Yuh-Ying Yeh, Natarajan Muthusamy, David Jarjoura, Xiaokui Mo, Liwen Wang, Sarwish Rafiq, Asha Ramanunni, Rosa Lapalombella, Brian J. Lannutti, Rajeswaran Mani, Susheela Tridandapani, Peter A. Thompson, Nyla A. Heerema, Justin Staubli, Gerard Lozanski, Michael A. Freitas, Scott Stromatt, John C. Byrd, Amy J. Johnson, Leslie A. Andritsos
Publikováno v:
Cancer cell. 21(5)
SummaryTetraspanins are commonly believed to act only as “molecular facilitators,” with no direct role in signal transduction. We herein demonstrate that upon ligation, CD37, a tetraspanin molecule expressed on mature normal and transformed B cel
Autor:
Diane D. Fang, Frederic Princen, Valeria Poli, Gen-Sheng Feng, Nissi Varki, Shuangwei Li, Jin Ding, Hongyang Wang, Emilie A. Bard-Chapeau, Sharon S. Zhang, Helen He Zhu, Tao Han, Béatrice Bailly-Maitre
Publikováno v:
Cancer cell. 19(5)
SummaryThe human gene Ptpn11, which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in several types of leukemia. Herein we report a tumor-suppressor function of Shp2. Hepa
Autor:
Jorge F. DiMartino, Yi Zheng, Jamie Wilhelm, James C. Mulloy, Jose A. Cancelas, Michael Jansen, Catherine Fox, Mark Wunderlich, Sara Alvarez, Junping Wei, Juan C. Cigudosa, Yi Gu
Publikováno v:
Cancer Cell. (6):483-495
SummaryFaithful modeling of mixed-lineage leukemia in murine cells has been difficult to achieve. We show that expression of MLL-AF9 in human CD34+ cells induces acute myeloid, lymphoid, or mixed-lineage leukemia in immunodeficient mice. Some leukemi
Autor:
Guido Kroemer, Jacques Pouysségur
Publikováno v:
Cancer Cell
Cancer Cell, Elsevier, 2008, 13 (6), pp.472-82. ⟨10.1016/j.ccr.2008.05.005⟩
Cancer Cell, Elsevier, 2008, 13 (6), pp.472-82. ⟨10.1016/j.ccr.2008.05.005⟩
The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic metabolism, either as a consequence or as a cause. As an example, the resistance of cancer mitochondria against apoptosis-associated permeabilization and the alte