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Autor:
Marc E. Lippman, Wenhua Tang, Meilan Liu, Shaomeng Wang, Mary A. Davis, Dajun Yang, James M. Rae, Theodore Lawrence, Jianyong Chen, Liang Xu
Publikováno v:
Cancer Biology & Therapy. 4:205-214
Microtubule-disrupting agents such as the taxanes comprise some of the most clinically useful chemotherapeutic agents and invoke the spindle checkpoint in proliferating cells. A robust spindle checkpoint in turn may forestall mitotic catastrophe, pot