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Publikováno v:
Cancer Biol Ther
Medulloblastoma is an aggressive primitive neuroectodermal tumor of the cerebellum that is more common in children than in adults. In the past decade, advances in understanding the molecular drivers of medulloblastoma have identified four molecular s
Autor:
Anjali Arora, Kumaravel Somasundaram
Publikováno v:
Cancer Biol Ther
Glioblastoma is the most invasive form of brain tumor. Although temozolomide chemotherapy has been shown to significantly improve survival in patients with GBM, this increase is only trivial. The underlying cause is that many GBMs do not respond to t
Autor:
Shaomian Qin, Junwei Wu, Hanqing Lin, Ying Dou, Zhiling Liao, Shoufeng Wang, Xiaowei Dong, Kai Liang, Naiquan Mao
Publikováno v:
Cancer Biology & Therapy. 20:150-156
NUT carcinoma (NC) is an aggressive squamous tumor characterized by NUT gene rearrangement, and the most common fusion form is BRD4-NUT. However, NC diagnosis is difficult for its rareness and often being confused with a variety of poorly differentia
Publikováno v:
Cancer Biology & Therapy
Cell-free DNA (cfDNA) has been a research hotspot in molecular tumor profiling. In advanced gastric cancer patients, malignant pleural effusion (MPE) and ascites provide a wealth of tumor cells that can be investigated. Here we conducted next-generat
Autor:
Georg Schäfer, Andrea Eigentler, Martin Zieher, Eberhard Steiner, Isabel Heidegger, Helmut Klocker, Josef Fritz, Andreas Pircher, Martin Puhr, Renate Pichler, Wolfgang Horninger
Publikováno v:
Cancer Biology & Therapy
Background: We investigated the role of diabetes mellitus (DM) and the molecular mechanisms of antidiabetic drugs in prostate cancer (PCa). Patients and Methods: 167 patients with both DM and PCa underwent radical prostatectomy (RPE). We divided our
Autor:
Eliya Shachar, Tali Ofir Dovrat, Ido Wolf, Ravit Geva, Garrett M. Frampton, Sharon Pelles, Ethan Sokol
Publikováno v:
Cancer Biology & Therapy. 19:871-874
Introduction: V600E BRAF mutation is an established driver mutation in a variety of tumors. Vemurafenib is a selective inhibitor of the BRAF V600E kinase, known to be highly effective in BRAF V600E-positive metastatic melanoma. As a single agent, vem
Publikováno v:
Cancer Biology & Therapy. 19:549-553
CD5-positive (CD5+) diffuse large B-cell lymphoma (DLBCL) is associated with poor survival compared with CD5-negative DLBCL. The clinical characteristics of CD5+ DLBCL are different from both CD5-negative DLBCL and other CD5+ B cell lymphomas. There
Autor:
Jing Liu, Jian Wang, Peikun Ding, Guanggui Ding, Lin Yang, Lu Zhang, Yuxin Wen, Tengfei Zhang
Publikováno v:
Cancer Biology & Therapy. 19:450-453
Afatinib exhibits therapeutic efficacy for lung adenocarcinoma patients harboring HER2 exon 20 insertions. HER2 S310Y single site substitution was discovered in recent years and afatinib efficacy for adenocarcinoma patients harboring S310Y mutation h
Autor:
Sebastian F. Schoppmann, Andrea Beer, Matthias Preusser, Werner Dolak, Peter Birner, Hossein Taghizadeh, Ahmed Ba-Ssalamah, Aysegül Ilhan-Mutlu, Michael Hejna
Publikováno v:
Cancer Biology & Therapy. 19:169-174
Attempts for identifying targeted therapy strategies in metastatic gastric and gastroesopheal junction cancer (upper-GI) revealed that the inhibition of human epidermal growth factor receptor-2 (HER2) by monoclonal antibody trastuzumab improves survi
Publikováno v:
Cancer Biology & Therapy. 18:984-989
The aim of this study was to determine whether photodynamic therapy (PDT) alone or combined with cisplatin (DDP), can deactivate cisplatin-resistant cancer cells. Human cancer cell lines A549 and SKOV3, and chemoresistant sublines A549/DDP and SKOV3/