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Autor:
Weiguo Jin, Ling-Feng Min, Chao Sun, Yiwei Fan, Xiaolin Wang, Hongcan Shi, Shichun Lu, Yusheng Shu
Publikováno v:
Cancer Biol Ther
Evidence suggests that Tripartite Motif Containing 11 (TRIM11) has pro-tumor activity in human non-small cell lung cancer (NSCLC). However, the roles and underlying mechanisms of TRIM11 in NSCLC have not yet been fully elucidated. In this work, human
Publikováno v:
Cancer Biol Ther
Chemokine (C-X-C motif) ligand 6 (CXCL6), a member of the CXC chemokine family, reportedly mediates several processes such as inflammation, immunoreaction, cell growth, and metastasis through interaction with the chemokine receptors CXCR1 and CXCR2 i
Publikováno v:
Cancer Biol Ther
Lung cancer remains the leading cause of cancer death in the United States. Since most lung cancers occur in aged individuals with chronic lung disorders characterized by inflammation and/or fibrosis, we hypothesized that aging and tissue inflammatio
Publikováno v:
Cancer Biol Ther
Signal transducer and activator of transcription 1 (STAT1) is related to the immune microenvironment of tumorigenesis. The programmed cell death 1 (PD-1) and its ligand (PD-L1) have been reported to be important in immunotherapy by mediating tumor im
Publikováno v:
Cancer Biology & Therapy. 21:863-870
Rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC) accounts for 1% of lung adenocarcinoma. Although small molecule agents with RET kinase inhibitory activity such as alectinib, vandetanib, and cabozantinib have be
Publikováno v:
Cancer Biol Ther
The recently renewed interest in scientific rigor and reproducibility is of critical importance for both scientists developing new targeted small-molecule inhibitors and those employing these molecule in cellular studies, alike. While off-target effe
Autor:
Scott A. Waldman, Amanda M. Pattison, Jeffrey A. Rappaport, Joshua R Barton, Alicja Zalewski, Adam E. Snook, Ariana A Entezari
Publikováno v:
Cancer Biology & Therapy. 21:799-805
Most sporadic colorectal cancer reflects acquired mutations in the adenomatous polyposis coli (APC) tumor suppressor gene, while germline heterozygosity for mutant APC produces the autosomal dominant disorder Familial Adenomatous Polyposis (FAP) with
Autor:
Edith P. Mitchell, Jeffrey A. Hooke, Serge Y. Fuchs, Hallgeir Rui, Yunguang Sun, Albert J. Kovatich, Hai Hu, Pengfei Yu, Olena Odnokoz, Amy R. Peck
Publikováno v:
Cancer Biol Ther
Within the microenvironment of solid tumors, stress associated with deficit of nutrients and oxygen as well as tumor-derived factors triggers the phosphorylation-dependent degradation of the IFNAR1 chain of type I interferon (IFN1) receptor and ensui
Autor:
Saad Alkahtani, Nefeli Zacharopoulou, Florian Lang, Christos Stournaras, Sotirios C. Kampranis, Evi Schmid, Galatea Kallergi, Anna Tsapara, Saud Alarifi, Basma Sukkar
Publikováno v:
Cancer Biol Ther
Recent studies revealed that the histone demethylase KDM2B regulates the epithelial markers E-Cadherin and ZO-1, the RhoA/B/C-small-GTPases and actin cytoskeleton organization, in DU-145 prostate- and HCT-116 colon-tumor cells. Here we addressed the
Autor:
Feda Azab, Cedric Mpoy, Jennifer Sun, Buck E. Rogers, Kinan Alhallak, Nilantha Bandara, Barbara Muz, Abdel Kareem Azab
Publikováno v:
Cancer Biology & Therapy. 21:52-60
Objective: Waldenstrom Macroglobulinemia (WM) is a rare B-cell malignancy characterized by secretion of immunoglobulin M and cancer infiltration in the bone marrow. Chemokine receptor such as CXCR...