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Publikováno v:
Cancer Biology & Therapy. 21:863-870
Rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC) accounts for 1% of lung adenocarcinoma. Although small molecule agents with RET kinase inhibitory activity such as alectinib, vandetanib, and cabozantinib have be
Publikováno v:
Cancer Biol Ther
Neuroblastoma is the most common malignancy in infants. Overexpression of the epidermal growth factor receptor (EGFR) in neuroblastoma tumors underlies resistance to chemotherapeutics. UBE4B, an E3/E4 ubiquitin ligase involved in EGFR degradation, is
Publikováno v:
Cancer Biol Ther
Medulloblastoma is an aggressive primitive neuroectodermal tumor of the cerebellum that is more common in children than in adults. In the past decade, advances in understanding the molecular drivers of medulloblastoma have identified four molecular s
Publikováno v:
Cancer Biol Ther
Background The prognostic value of Chemokine (C-X-C motif) ligand 1 (CXCL1) in various types of cancer remains controversial. Here we aimed to evaluate the prognostic role of CXCL1 for cancer. Methods A comprehensively search of the PubMed, Embase, W
Publikováno v:
Cancer Biology & Therapy. 20:397-401
Acute promyelocytic leukemia (APL) is one of the most fatal hematological malignancies. APL during pregnancy is a rare comorbidity and can lead to adverse outcomes, such as maternal and/or fetal death, without timely and appropriate management. Medic
Publikováno v:
Cancer Biology & Therapy. 19:1065-1071
Colorectal cancer (CRC) is ranked third as the most common malignancy, and it develops into metastasis at a high rate. Importantly, distant metastasis is considered to be a key factor for colorectal therapy. In the present study, we identified FOXD4,
Autor:
Cheng Chen, Tian Xue, Ke Deng, Qingsong Liu, Hong Li, Wenchu Lin, Mei Zhang, Ming Li, Huan Zhao, Hong Bo, Vivian Wai Yan Lui, Wei Wang, Jiawei Shen
Publikováno v:
Cancer Biology & Therapy. 20:52-64
Small cell lung cancer (SCLC) is a malignant neuroendocrine tumor with very high mortality. Effective new therapy for advanced SCLC patients is urgently needed. By screening a FDA-approved drug library, we identified a cardiac glycoside (CG), namely
Autor:
Alshad S. Lalani, Paul Dent, Francesca Avogadri-Connors, John M. Kirkwood, Richard E. Cutler, Laurence Booth, Jane L. Roberts, Cindy Sander, Andrew Poklepovic
Publikováno v:
Cancer Biology & Therapy
The FDA approved irreversible inhibitor of ERBB1/2/4, neratinib, was recently shown to rapidly down-regulate the expression of ERBB1/2/4 as well as the levels of c-MET and mutant K-RAS via autophagic degradation. In the present studies, in a dose-dep
Autor:
Stephan Hackenberg, Philipp Schendzielorz, Rudolf Hagen, Norbert Kleinsasser, Thomas Gehrke, Agmal Scherzad, Pascal Ickrath
Publikováno v:
Cancer Biology & Therapy. 18:513-518
Zinc oxide nanoparticles (ZnO-NPs) are being used in many cosmetic products and have been shown to induce tumor-selective cell death in human head and neck squamous cell carcinoma (HNSCC) in vitro. Cetuximab is a monoclonal antibody directed against
Autor:
Yu-Jie Zhang, Ling-Ling Li, You-Yi Liu, Jian Wu, Jian-Jun Zhu, Lei-Rong Xu, Fei-Fei Chen, Feng Bi, Weiwei Wang, Anquan Shang
Publikováno v:
Cancer Biology & Therapy. 18:314-322
Objective: The study aims to explore the relationship between expressions of HER2 and JAK/STAT3-SOCS3 signaling pathway and clinicopathological features and prognosis of ovarian cancer (OC).Methods: A total of 136 OC patients were collected. Immunohi