Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Nakanishi A"'
Autor:
Akiko Fujii, Shinya Sakata, Keita Nakatomi, Yoichi Nakanishi, Ryo Toyozawa, Koji Inoue, Noriko Hidaka, Kazuko Sakai, Isamu Okamoto, Keiichi Ota, Junji Kishimoto, Taishi Harada, Eiji Iwama, Kazuto Nishio, Junko Hisasue, Takayuki Shimose, Koichi Azuma, Noriaki Nakagaki
Publikováno v:
Cancer. 126:219-227
BACKGROUND The aim of this study was to evaluate the potential of liquid biopsy for prediction of the efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) treatment and for assessment of the changes in genetic alteratio
Autor:
Yoichi Nakanishi, Tomonori Hirashima, Masayuki Takeda, Haruko Daga, Takashi Seto, Hidetoshi Hayashi, Shunichi Sugawara, Isamu Okamoto, Toshiyuki Sawa, Naoyuki Nogami, Morihito Okada, Kazuhiko Nakagawa, Haruhiro Saito, Koichi Azuma, Takeharu Yamanaka, Akihito Kubo, Kimio Yonesaka, Yoshiko Urata, Eiji Miyahara, Haruyasu Murakami
Publikováno v:
Cancer. 122(7)
BACKGROUND Bevacizumab combined with platinum-based chemotherapy has been established as a standard treatment option in the first-line setting for advanced nonsquamous non–small cell lung cancer (NSCLC). However, there has been no evidence to suppo
Autor:
Kazuhiko Nakagawa, Hisao Uejima, Tatsuhiko Kashii, Minoru Takada, Kaoru Matsui, Y. Takada, Nobuyuki Yamamoto, Yoichi Nakanishi, Takahiko Sugiura, Terufumi Kato, Shun Ichi Negoro, Masahiro Fukuoka
Publikováno v:
Cancer. 107:599-605
BACKGROUND. Combined gemcitabine and carboplatin (GC) and combined gemcitabine and vinorelbine (GV) are active and well tolerated chemotherapeutic regimens for patients with advanced nonsmall cell lung cancer (NSCLC). The authors conducted a randomiz
Publikováno v:
Cancer. 103:307-312
BACKGROUND Patients with hepatocellular carcinoma (HCC) who showed early massive disease recurrence due to hematogenous intrahepatic metastasis after curative resection had a poor prognosis. The authors previously reported that Akt phosphorylation wa
Autor:
Setsuo Hirohashi, Yuko Sasajima, Yukihiro Nakanishi, Katsumi Hanada, Naoya Yamazaki, Aya Nishizawa, Kimio Yoshimura, Yae Kanai, Akifumi Yamamoto
Publikováno v:
Cancer. 103:1693-1700
BACKGROUND The E-cadherin–mediated cell adhesion system is frequently inactivated by multiple mechanisms and is involved in tumor progression in many types of cancer. Recently, the authors reported a novel cell membrane glycoprotein, dysadherin, wh
Autor:
Yong Nan Li, Tsuneharu Miki, Hiroyuki Nakanishi, Osamu Yoshida, Yoichi Mizutani, Masakazu Fukushima, Hiromi Wada
Publikováno v:
Cancer. 100:723-731
BACKGROUND 5-Fluorouracil (5-FU), an antitumor agent, is used clinically against a variety of malignancies, including bladder carcinoma. 5-FU is a prodrug, and orotate phosphoribosyltransferase (OPRT) is the principal enzyme that converts 5-FU direct
Autor:
Steven W. Martin, Allan Lipton, Pirow Bekker, Jean-Jacques Body, Philip Greipp, Xavier Mariette, Filip Geurs, Jean-Paul Fermand, Arline Nakanishi, Jean-Luc Harousseau, Catherine D. Williams, Colin R. Dunstan, Donna Holloway, Thierry Facon, Robert E. Coleman
Publikováno v:
Cancer. 97:887-892
BACKGROUND Osteoprotegerin (OPG) is a decoy receptor for OPG ligand (OPGL), or receptor activator of NF-κB ligand (RANKL). RANKL/RANK interaction is important in terminal differentiation and activation of osteoclasts. In binding to RANKL, OPG blocks
Autor:
Yoichi Nakanishi, Miiru Izumi, Hiroshi Wataya, Takahiro Minami, Koji Inoue, Kanehito Kimotsuki, Nobuyuki Hara, Koichi Takayama
Publikováno v:
Cancer. 91:1487-1493
BACKGROUND Several biochemical markers of bone formation and bone resorption have been developed recently. The authors evaluated the usefulness of new biomarkers, such as urinary deoxypyridinoline (D-PYD), serum pyridinoline cross-linked C-telopeptid
Immunohistochemically detected micrometastases of the lymph nodes in patients with gastric carcinoma
Autor:
Keiichi Maruyama, Yukihiro Nakanishi, Mitsuru Sasako, Hitoshi Katai, Takeo Fukagawa, Takeshi Sano, Tadakazu Shimoda, Gregory Bruce Mann
Publikováno v:
Cancer. 92:753-760
BACKGROUND Lymph node status is a major determinant of disease recurrence after patients undergo curative resection for gastric carcinoma. A proportion of patients without lymph node metastasis develop systemic recurrences. Recent studies in a range
Autor:
Masaharu Takigawa, Hajime Inoue, Keiichiro Nishida, Nobuya Ohara, Takeshi Doi, Toshihiko Shakunaga, Toshifumi Ozaki, Akira Kawai, Koji Asaumi, Tohru Nakanishi
Publikováno v:
Cancer. 89:1466-1473
BACKGROUND Connective tissue growth factor (CTGF) predominantly is expressed in hypertrophic chondrocytes and its specific receptors are demonstrated on chondrocytic cells. Therefore, CTGF may be involved in the proliferation and/or differentiation o