Zobrazeno 1 - 10
of 306
pro vyhledávání: ''
Autor:
Rutika Mehta, Barbara A. Centeno, Richard D. Kim, Elaine S Tan, Biwei Cao, Jongphil Kim, Taymeyah Al-Toubah
Publikováno v:
Cancer. 127:1293-1300
Background Biliary tract cancer (BTC) has a poor prognosis despite treatment with first-line gemcitabine and cisplatin. In BTC, PI3K/AKT pathway activation has been shown to increase resistance to chemotherapy, which may be overcome with PI3K inhibit
Autor:
Eliezer M. Van Allen, Ilana Rebecca Garcia-Grossman, Azeez Farooki, Irina Ostrovnaya, Matthew I. Milowsky, Brendan Reardon, Asia S. McCoy, Andrew J. Roth, Aravind Bhayankara, Mariel Elena Boyd, Victor McPherson, David B. Solit, Michael F. Berger, Dean F. Bajorin, Philip H. Kim, Hikmat Al-Ahmadie, Gopa Iyer, Jonathan E. Rosenberg, Ashley Marie Regazzi, Sasinya N. Scott
Publikováno v:
Cancer
Background The phosphatidyl 3-inositol kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway frequently is activated in patients with urothelial carcinoma (UC). In the current study, the authors performed a phase 2 study evaluating the eff
Autor:
Byoung Chul Cho, Seong Gu Heo, Young Joo Min, Keon Uk Park, Hyo Song Kim, Tae Min Kim, Min Kyoung Kim, Kyu Ryung Kim, Ik Joo Chung, Yun Gyoo Lee, Hye Ryun Kim, Min Hee Hong, Yoon Ho Ko, Hoon Gu Kim, Jinseon Yoo
Publikováno v:
Cancer. 126:4521-4531
Background The objective of the current study was to investigate the clinical activity of, safety of, and predictive biomarkers for afatinib, an irreversible pan-ErbB kinase inhibitor, in patients with recurrent and/or metastatic esophageal squamous
Autor:
Susanne K. Pedersen, Frederick S. Jones, Christos S. Karapetis, David M. Murray, Susan E Byrne, Paul Hollington, Eva Segelov, Graeme P. Young, Philippa Rabbitt, Amitesh Roy, Lawrence C. LaPointe, Erin L. Symonds
Publikováno v:
Cancer
Background The sensitive detection of recurrent colorectal cancer (CRC) by the measurement of circulating tumor DNA (ctDNA) might improve the chance of a cure. This study compared a quantitative methylated ctDNA test with carcinoembryonic antigen (CE
Autor:
Elisa Ledet, Mehmet Asim Bilen, Guru Sonpavde, Petros Grivas, Jue Wang, Rebecca J. Nagy, Michael B. Lilly, Gurudatta Naik, Shilpa Gupta, Amir Ali Talasaz, Lakshminarayanan Nandagopal, Oliver Sartor, Roberto Nussenzveig, Andrew W. Hahn, Gregory R. Pond, Sumanta K. Pal, Richard B. Lanman, Neeraj Agarwal, Theodore Stewart Gourdin, Andrew J. Armstrong
Publikováno v:
Cancer. 125:1459-1469
Background Because cell-free DNA (cfDNA) analysis facilitates the noninvasive genomic profiling of metastatic castration-resistant prostate cancer (mCRPC), the authors evaluated the association between cfDNA alterations and outcomes and evolution wit
Autor:
Alessandra Ferrajoli, Rajyalakshmi Luthra, Joseph D. Khoury, Rashmi Kanagal-Shamanna, Zeev Estrov, Michael J. Keating, Mark J. Routbort, Keyur P. Patel, Carlos E. Bueso-Ramos, Jan A. Burger, William G. Wierda, Preetesh Jain, Tahani Alhalouli, L. Jeffrey Medeiros, Nitin Jain, Hagop M. Kantarjian
Publikováno v:
Cancer. 125:559-574
Background In a proportion of patients with chronic lymphocytic leukemia (CLL), resistance to Bruton tyrosine kinase (BTK) inhibitors (BTKi) is attributed to acquired BTK/phospholipase C gamma 2 (PLCG2) mutations. However, knowledge regarding additio
Autor:
Karthikeyan Murugesan, Garrett M. Frampton, Razelle Kurzrock, Vi Nguyen, Austin J. Parish, Aaron M. Goodman
Publikováno v:
Cancer. 124:4080-4089
BACKGROUND Advances in deep sequencing technology have uncovered a widespread, protumorigenic role of guanine nucleotide-binding (G protein) α (GNA) subunits, particularly GNA subunits Gs (GNAS), Gq (GNAQ), and G11 (GNA11) (GNA*), in a diverse colle
Autor:
B. Miles, Gypsyamber D'Souza, Tanya Troy, Rajarsi Mandal, Melina J. Windon, C. Matthew Stewart, Wade W. Chien, Wojciech K. Mydlarz, Christine G. Gourin, Lee M. Akst, Alexander T. Hillel, Carole Fakhry, Tim Waterboer, Virginia E. Drake, Patrick K. Ha, Lisa M. Rooper, David W. Eisele, Siddhartha Yavvari, Nicole Brenner
Publikováno v:
Cancer
Background Case-control studies from the early 2000s demonstrated that human papillomavirus-related oropharyngeal cancer (HPV-OPC) is a distinct entity associated with number of oral sex partners. Using contemporary data, we investigated novel risk f
Autor:
Himisha Beltran, Bradley B. Pua, Brian D. Robinson, Juan Miguel Mosquera, Luis S Beltran, Olivier Elemento, David M. Nanus, Marc H. Schiffman, Andrea Sboner, Mark A. Rubin, Adam D. Talenfeld, Chantal Pauli, Alexandros Sigaras, Rohan Bareja, Verena Sailer, Kyungmouk Steve Lee, Brian L. Sullivan, Rema Rao, Scott T. Tagawa, Joanna Cyrta, Myriam Kossai, Shaham Beg, Kenneth Eng
Publikováno v:
Cancer. 124:1008-1015
BACKGROUND Metastatic biopsies are increasingly being performed in patients with advanced prostate cancer to search for actionable targets and/or to identify emerging resistance mechanisms. Due to a predominance of bone metastases and their sclerotic
Autor:
Mackenzie L. Myers, Elena Pentsova, Maria E. Arcila, Mark G. Kris, Robert J. Young, Adrienne Boire, Ai Ni, Kathryn Beal, David R. Jones, Lisa M. DeAngelis, W. Victoria Lai, James M. Isbell, Helena A. Yu, Viviane Tabar, Gregory J. Riely, Mariza Daras, Charles M. Rudin, Bob T. Li, Emmet Jordan, Alexander Drilon, Daniel Feldman, David B. Solit, M. Offin
Publikováno v:
Cancer. 125(24)
BACKGROUND Mutations in human epidermal growth factor receptor 2 (HER2; also known as ERBB2) are found in approximately 2% of lung adenocarcinomas. The frequency and clinical course of brain metastases in this oncogenic subset are ill defined. METHOD