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Autor:
Stephen J. Meltzer, Zhixiong Wang, Wei Chen, Xi Liu, Xiquan Ke, Rong Yan, Sariat Ibrahim, Gary P. Schroth, Yulan Cheng, Yulong He, John M. Abraham
Publikováno v:
Cancer. 123:3916-3924
BACKGROUND Studies of chromosomal rearrangements and fusion transcripts have elucidated mechanisms of tumorigenesis and led to targeted cancer therapies. This study was aimed at identifying novel fusion transcripts in esophageal adenocarcinoma (EAC).
Autor:
Steven L. Salzberg, Daehwan Kim, Stephen J. Meltzer, Yulan Cheng, Xiquan Ke, Jee Hoon Song, Sariat Ibrahim, Zhenguo Sun, Hui Tian, Valentin Antonescu, Binbin Huang, John M. Abraham
Publikováno v:
Cancer. 123:1507-1515
BACKGROUND Novel fusion transcripts (FTs) caused by chromosomal rearrangement are common factors in the development of cancers. In the current study, the authors used massively parallel RNA sequencing to identify new FTs in colon cancers. METHODS RNA
Autor:
M. Kay Washington, Uma Krishna, Abbes Belkhiri, M. Blanca Piazuelo, Judith Romero-Gallo, Richard M. Peek, Wael El-Rifai, Ahmed M. Katsha, Zheng Chen, Mohammed Soutto
Publikováno v:
Cancer. 121:4348-4358
BACKGROUND Infection with Helicobacter pylori, a high-risk factor for gastric cancer, is frequently associated with chronic inflammation through activation of nuclear factor κB (NF-κB). Trefoil factor 1 (TFF1) is a constitutively expressed protein
Autor:
Meilin Wang, Linjun Zhu, Zhengdong Zhang, Jing Jin, Xiaonan Qiu, Qiuhan Hua, Gaoyun Hui, Haiyan Chu, Liping Xia, Na Tong, Mulong Du, Dongying Gu, Jinfei Chen
Publikováno v:
Cancer. 121:2044-2052
BACKGROUND PIWI-interacting RNAs (piRNAs), which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in germline development and carcinogenesis. METHODS By systematically screening all known piRNAs, the authors identified
Autor:
Martin Simon Kalteis, Justo Lorenzo Bermejo, Elena Sophie Prigge, Nadine Olthof, Simon F. Preuss, Ernst-Jan M. Speel, Steffen Wagner, Miriam Reuschenbach, Jens Peter Klussmann, Christian U. Huebbers, Magnus von Knebel Doeberitz, Bernd Kremer, Svetlana Vinokurova, Jutta Kolligs, Inga M. C. Seuthe
Publikováno v:
Cancer. 121:1966-1976
BACKGROUND The human papillomavirus (HPV) E2 protein is a transcriptional repressor of the oncogenes E6/E7 and loss of E2 function is considered a key step in carcinogenesis. Integration of HPV into the host genome may disrupt the E2 gene. Furthermor
Autor:
Diana P. English, Carlton L. Schwab, Emiliano Cocco, Alessandro D. Santin, Dan-Arin Silasi, Elena Bonazzoli, Thomas J. Rutherford, Peter E. Schwartz, Masoud Azodi, Ileana Bortolomai, Elena Ratner, Dana M. Roque, Sudeshna Chatterjee, Salvatore Lopez, Stefania Bellone
Publikováno v:
Cancer. 121:403-412
BACKGROUND: Solitomab is a novel, bispecific, single-chain antibody that targets epithelial cell adhesion molecule (EpCAM) on tumor cells and also contains a cluster of differentiation 3 (CD3) (T-cell coreceptor) binding region. The authors evaluated
Autor:
David G. Mutch, Julie A. Stephens, Adrian A. Suarez, David E. Cohn, Caroline C. Billingsley, Paul J. Goodfellow
Publikováno v:
Cancer. 121:386-394
Cancers have a mutator phenotype [1]. An elevated mutation rate is central to tumorigenesis in human malignancies and significantly contributes to the disruption of regulatory processes essential to genomic stability. Endometrial cancers (ECs) are fr
Autor:
Yiming Zhang, Jin Li, Yiming Lai, Huimin Zhou, Lexiang Zeng, Jieqing Chen, Ganping Wang, Hai Huang, Tao Du, Zhenghui Guo, Yi Cao
Publikováno v:
Cancer. 120:3208-3218
BACKGROUND Nuclear factor κB (NFκB) signaling is strongly associated with tumor progression, and studies have shown that SHANK-associated RH domain interacting protein (SHARPIN) is crucial for NFκB pathway activation. However, the expression and f
Publikováno v:
Cancer. 120:2412-2423
BACKGROUND F-box protein 32 (FBXO32) (also known as atrogin-1), a member of the F-box protein family, has recently been identified as a transforming growth factor beta (TGF-β)/Smad target gene involved in regulating cell survival, and it may be tran
Publikováno v:
Cancer. 120:579-588
BACKGROUND RE1-silencing transcription factor (REST), a neuronal repressor gene, regulates neuronal stem cell differentiation. Ewing sarcoma may originate from neural crest cells. In the current study, the authors investigated whether REST plays a ro