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Publikováno v:
Canadian Journal of Physiology and Pharmacology. 69:846-851
Opioid peptides have been implicated in shock-associated hypotension. Our aim was to find out whether opioid agonists have direct vasodilator actions on vascular smooth muscle. The study was conducted on rat abdominal aortic rings. In rings precontra
Autor:
A. B. R. Thomson, Monika Keelan
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 69:592-598
This study was undertaken to examine the effect of supplementing chow for 2 weeks with 2% cheno- (CDC) or ursodeoxycholic (UDC) acid or cholestyramine (CHOL) on the intestinal morphology and in vitro uptake of bile acids in adult rats. Food intake wa
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 69:185-190
Immature female rats treated with superovulatory doses of pregnant mare serum gonadotropin (PMSG) were used to study the effects of the antiandrogen hydroxyflutamide on steroid production, particularly the biologically active androgens, in two experi
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 68:1286-1291
Choleresis induced by dehydrocholate (DHC) stimulates the discharge into bile of lysosomes, which are implicated in the biliary excretion of proteins. Contrary to taurocholate-induced choleresis, DHC choleresis is not affected by microtubule (mt) inh
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 68:586-595
The actions of serotonin (5-HT) and its putative agonists and antagonists were examined in vitro on hippocampal CA1 neurons using intracellular recordings, demonstrating that the cellular pharmacological effects can not necessarily be predicted from
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 68:28-33
Polycystic ovaries (PCO) develop in female rats within 4 weeks of an injection of estradiol valerate (EV). The final morphological transition from a noncystic to a cystic state occurs in the presence of estrous (control) mean serum gonadotropin conce
Publikováno v:
Canadian journal of physiology and pharmacology. 69(8)
The potential interaction (s) between atrial natriuretic factor (ANF) and porcine–human endothelin (ET-1) was investigated in the endothelium-denuded rat aortic ring preparation. ET-1 produced a sustained contraction of aortic rings with an ED50 of
Publikováno v:
Canadian journal of physiology and pharmacology. 69(6)
In the late distal and cortical collecting tubule, which is the principal regulatory site for potassium (K) excretion, vasopressin stimulates, and epinephrine via β-adrenergic action, inhibits K secretion. In the inner medullary collecting duct (IMC
Autor:
N. J. Boudreau, M. M. Vohra
Publikováno v:
Canadian journal of physiology and pharmacology. 69(4)
In this study the mechanism by which histamine and H1 and H2 agonists evoked an overflow of radioactivity from rat vasa deferentia preloaded with [3H]noradrenaline was investigated. The overflow evoked by the various agonists was unaffected by the pr
Publikováno v:
Canadian journal of physiology and pharmacology. 69(3)
Smooth muscle cells were dissociated from conducting cerebral arteries of adult rats and maintained in culture for 2–4 days. The calcium-sensitive fluorescent probe, fura-2, was used to study the effect of the vasoconstrictor serotonin (5-HT) on th