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Publikováno v:
Canadian journal of physiology and pharmacology. 99(9)
The present study aims to explore the role of microRNA 145-5p (miR-145-5p) in hyperlipidemia. Using bioinformatics tools and a wide range of function and mechanism assays, we attempted to understand the specific function and potential mechanism of mi
Autor:
Enas M Moustafa, Noura M Thabet
Publikováno v:
Canadian journal of physiology and pharmacology. 95(6)
This study was designed to evaluate the effect of beta-sitosterol (BS) on the peroxisome proliferator-activated receptor gamma (PPAR-γ) gene expression role in the activity of paraoxonase (PON-1) enzyme in oxidative stress status of irradiated rats.
Autor:
Boyina Hemanth Kumar, B. Dinesh Kumar, Ravula Arun Reddy, Jerald Mahesh Kumar, Prakash V. Diwan
Publikováno v:
Canadian journal of physiology and pharmacology. 95(1)
This study was designed to investigate the effects of fisetin (FST) on hyperhomocysteinemia (HHcy)-induced experimental endothelial dysfunction (ED) and vascular dementia (VaD) in rats. Wistar rats were randomly divided into 8 groups: control, vehicl
Publikováno v:
Canadian journal of physiology and pharmacology. 95(2)
This study aimed to investigate effects of curcumin on high fructose diet (HFD)-induced metabolic syndrome (MetS) in rats and the possible mechanisms involved. MetS was induced in male albino rats (n = 20), over 8 weeks, by 65% HFD. For 8-week experi
Autor:
Gomedhikam J Prakash, Chitrapu R.V. Chalam, K. Madan, K. M. Krishna, Akula Annapurna, Gopisetty S. Gopal, Veeravalli K. Kumar
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 83:343-355
The present investigation was carried out to evaluate the effects of the cyclodextrin complexes quercetin and rutin on left ventricle dysfunction in streptozotocin-induced diabetic rats. Diabetes was induced by streptozotocin (45 mg/kg body mass, i.v
Autor:
Hosana G. Rodrigues, Ethel L. B. Novelli, L. A. Faine, Cristiano M. Galhardi, Antonio Carlos Cicogna, Y. S. Diniz, Regina Coeli Vasques de Miranda Burneiko, Léa Silvia Sant'Ana
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 82:969-975
Caloric intake is higher than recommended in many populations. Therefore, enhancing olive oil intake alone may not be the most effective way to prevent cardiovascular diseases. The purpose of the present study was to analyse the association of olive
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 81:1139-1146
Stress has been implicated in the etiopathogenesis of several diseases. In the present study, the effects of acute (AS), chronic (CS), and chronic unpredictable stress (CUS) were studied on the ulcer index, adrenal gland mass, and biochemical and hor
Publikováno v:
Canadian journal of physiology and pharmacology. 91(9)
We aimed to investigate whether atorvastatin influenced the CD40–CD40L pathway in atherosclerosis formation in rats fed a high cholesterol diet. Thirty-six male Wistar rats were divided among 4 groups as follows: control (C), statin (S), 5% cholest
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 72:771-781
The effects of fructose loading on the integrated cardiovascular function in vivo, glycemic control, glucose tolerance, and plasma lipid levels in nondiabetic and streptozotocin (STZ) diabetic rats were investigated. Endothelial morphology of the tho
Autor:
John H. McNeill, Soter Dai
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 70:1583-1589
The present study compares the cardiovascular consequences of a 6-week fructose feeding in nondiabetic and streptozotocin-diabetic rats. Myocardial performance of these animals was determined using the isolated perfused working heart preparation. Sys