Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Dashyant Dhanak"'
Autor:
Richard M. Keenan, Henry M. Sarau, Nambi Aiyar, David J. Behm, Schmidt Stanley J, Lisa T. Christmann, Steven D. Knight, William E. Wixted, Lance Ridgers, Peter T. Buckley, Timothy Francis Gallagher, James J. Foley, Graham J. Riley, John G Gleason, Jyoti Disa, Diane Naselsky, Dashyant Dhanak, Stephen A. Douglas, Jian Jin, Widdowson Katherine L, Dulcie B. Schmidt, David P. Brooks, Eliot H. Ohlstein
Publikováno v:
British Journal of Pharmacology. 145:620-635
1. SB-706375 potently inhibited [(125)I]hU-II binding to both mammalian recombinant and 'native' UT receptors (K(i) 4.7+/-1.5 to 20.7+/-3.6 nM at rodent, feline and primate recombinant UT receptors and K(i) 5.4+/-0.4 nM at the endogenous UT receptor
Autor:
Eliot H. Ohlstein, Christopher L Herold, Dashyant Dhanak, Steven D. Knight, Stephen A. Douglas, David J. Behm
Publikováno v:
British Journal of Pharmacology. 137:449-458
1. Human urotensin-II (hU-II), a cyclic undecapeptide, is amongst the most potent mammalian vasoconstrictors identified, suggesting that hU-II and its G-protein-coupled receptor (UT) may regulate cardiovascular homeostasis. Such a hypothesis would be