Zobrazeno 1 - 10
of 1 325
pro vyhledávání: ''
Publikováno v:
British Journal of Pharmacology. 179:2193-2207
Background and purpose Glucosylsphingosine (GS), an endogenous sphingolipid, is highly accumulated in the epidermis of patients with atopic dermatitis (AD) due to abnormal ceramide metabolism. More importantly, GS can evoke scratching behaviors. Howe
Publikováno v:
British Journal of Pharmacology. 179:1338-1352
BACKGROUND AND PURPOSE Prostacyclin mimetics express potent vsoactive effects via prostanoid receptors which are not defined unequivocally, as to date no study has considered sex as a factor. The aim of this study was to determine the contribution of
Autor:
Viviana Casagrande, Massimo Federici, Germana Cocozza, Heike Wulff, Rossella Menghini, Marta Morotti, Marcello Raspa, Stefano Garofalo, Giuseppina Chece, Cristina Limatola, Alfonso Grimaldi, Ferdinando Scavizzi, Mario Lecce
Publikováno v:
British Journal of Pharmacology. 178:4891-4906
BACKGROUND AND PURPOSE Amyotrophic lateral sclerosis (ALS) patients exhibit dysfunctional energy metabolism and weight loss, which is negatively correlated with survival, together with neuroinflammation. However, the possible contribution of neuroinf
Autor:
Beáta Sperlágh, András Iring, Mária Baranyi, Zoltán Benyó, László Hricisák, Flóra Gölöncsér, Lilla Otrokocsi
Publikováno v:
British Journal of Pharmacology. 178:4626-4645
Background and purpose P2Y12 receptors regulate different forms of pain and inflammation. In this study, we investigated the participation of P2Y12 receptors in an animal model of migraine. Experimental approach We tested the effect of the centrally
Publikováno v:
British Journal of Pharmacology. 178:4842-4858
Background and purpose In addition to binding to the classical high-affinity extracellular benzodiazepine binding site of the GABAA receptor, some benzodiazepines occupy transmembrane inter-subunit anesthetic sites that bind etomidate (β+ /α- sites
Autor:
Alexander Samoshkin, Jeffrey S. Mogil, Jing Wang, Alexander Linton, Arjun Muralidharan, Marino Convertino, Changyu Jiang, William Maixner, Richard Klares, Ru-Rong Ji, Marjo Piltonen, Nikolay V. Dokholyan, Pavel Gris, Luda Diatchenko
Publikováno v:
British Journal of Pharmacology. 178:2709-2726
Background and purpose The μ-opioid receptor (μ receptor) is the primary target for opioid analgesics. The 7-transmembrane (TM) and 6TM μ receptor isoforms mediate inhibitory and excitatory cellular effects. Here, we developed compounds selective
Autor:
Samuel Singleton, Tim G. Hales, Ewan Camplisson, Emily Edelsten, Kirsty S. McCaughey, Daniel T. Baptista-Hon
Publikováno v:
British Journal of Pharmacology. 178:1855-1868
Background and purpose β-Arrestin2 recruitment to μ-receptors may contribute to the development of opioid side effects. This possibility led to the development of TRV130 and PZM21, opioids reportedly biased against β-arrestin2 recruitment in favou
Autor:
Anna Pittaluga
Publikováno v:
British Journal of Pharmacology. 178:1001-1017
The existence of presynaptic, release-regulating N-methyl-D-aspartate receptors (NMDARs) in the central nervous system (CNS) has been long matter of discussion. Most of the reviews dedicated to support this conclusion preferentially focussed on the r
Autor:
Robert Seaman, Yanan Zhang, Jian-Feng Liu, Bernard Johnson, Ruyan Wu, Jimmy Vu, Jun-Xu Li, Jingwei Tian
Publikováno v:
Br J Pharmacol
Background and purpose Trace amine-associated TA1 receptors play critical roles in regulating dopamine transmission. Previous studies showed that pharmacologically or genetically manipulating the activity of TA1 receptors modulates addiction-like beh
Autor:
Nils Ole Dalby, Bente Frølund, Ulrike Leurs, Petrine Wellendorph, Christina Birkedahl Falk-Petersen, Petra Scholze, Jacob Krall
Publikováno v:
British Journal of Pharmacology. 177:3975-3990
Background and purpose The δ-subunit-containing GABAA receptors, α4 β1 δ and α4 β3 δ, in dentate gyrus granule cells (DGGCs) are known to exhibit both spontaneous channel openings (i.e. constitutive activity) and agonist-induced current. The f