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Publikováno v:
British Journal of Pharmacology. 179:1338-1352
BACKGROUND AND PURPOSE Prostacyclin mimetics express potent vsoactive effects via prostanoid receptors which are not defined unequivocally, as to date no study has considered sex as a factor. The aim of this study was to determine the contribution of
Autor:
Jin-Zi Ji, Peng-Xin Ge, Qiong-Yu Mi, Ting Zhu, Ting Tai, Hong-Guang Xie, Li-Ping Jiang, Yi-Fei Li
Publikováno v:
British Journal of Pharmacology. 179:46-64
Background and purpose Overweight or obese patients exhibit poorer platelet responses to clopidogrel; however, the mechanisms behind this phenotype remain to be elucidated. Here, we sought to dissect whether and why obesity could affect the metabolic
Autor:
Eunju Leem, Hyung-Jun Kim, Youngpyo Nam, Won-Ho Shin, Sang Ryong Kim, Chang-Won Hong, Sehwan Kim, Byung Kwan Jin, Chanchal Sharma, Kyu-Sung Kim, Dong Woon Kim, Shinrye Lee, Catriona McLean, Do-Geun Kim, Jaekwang Kim, Gyeong Joon Moon, Chang Man Ha, Yong-Seok Oh
Publikováno v:
British Journal of Pharmacology. 179:998-1016
BACKGROUND AND PURPOSE There is a scarcity of information regarding the role of prothrombin kringle-2 (pKr-2), which can be generated by active thrombin, in hippocampal neurodegeneration and Alzheimer's disease (AD). EXPERIMENTAL APPROACH To assess t
Autor:
Viviana Casagrande, Massimo Federici, Germana Cocozza, Heike Wulff, Rossella Menghini, Marta Morotti, Marcello Raspa, Stefano Garofalo, Giuseppina Chece, Cristina Limatola, Alfonso Grimaldi, Ferdinando Scavizzi, Mario Lecce
Publikováno v:
British Journal of Pharmacology. 178:4891-4906
BACKGROUND AND PURPOSE Amyotrophic lateral sclerosis (ALS) patients exhibit dysfunctional energy metabolism and weight loss, which is negatively correlated with survival, together with neuroinflammation. However, the possible contribution of neuroinf
Publikováno v:
British Journal of Pharmacology. 178:4808-4825
Background and purpose Modafinil is a potent eugeroic (wakefulness-promoting) drug that is prescribed to treat narcolepsy and has a low incidence of abuse. Although previous studies have shown that modafinil-induced arousal depends on the dopamine re
Autor:
Xiao Hu, Hui Ding, Su-Ying Cui, Yu Qin, Nurhumar Kurban, Yong-He Zhang, Hui-Ling Zhao, Xiang-Yu Cui, Yu-Tong Liu
Publikováno v:
British Journal of Pharmacology. 178:3696-3707
Background and purpose Mineralocorticoid receptors (MRs), glucocorticoid receptors (GRs) and corticotropin-releasing factor (CRF) in the paraventricular nucleus of hypothalamus (PVN) are involved in the response to stress. The present study investiga
Autor:
Antonino Bongiovanni, Florent Auger, Sandrine Bergeron, Charlotte Laloux, Yaohua Chen, Camille Potey, Sophie Gautier, Régis Bordet, Aurélie Jonneaux, Clémence Leboullenger, Romain Barus, Meryem Tardivel
Publikováno v:
British Journal of Pharmacology. 178:1705-1721
BACKGROUND AND PURPOSES Cerebral microhaemorrhages (CMHs) are associated with cognitive decline in humans. In rodents, CMHs induces cognitive impairment in male mice along with sex-specific cortical and hippocampal changes affecting neural, glial and
Autor:
Shaun L. Sandow, Irit Markus, Dana S. Hutchinson, Fiona C. Britton, Samantha L. Saunders, Timothy V. Murphy, Lu Liu
Publikováno v:
British Journal of Pharmacology. 178:1789-1804
BACKGROUND AND PURPOSE The physiological role of vascular β3 -adrenoceptors is not fully understood. Recent evidence suggests cardiac β3 -adrenoceptors are functionally effective after down-regulation of β1 /β2 -adrenoceptors. The functional inte
Autor:
Dorothee Römermann, Ursula Seidler, Xiu Renjie, Gabriella di Stefano, Xinjie Tan, Steven R. Talbot, Qinghai Tan
Publikováno v:
British Journal of Pharmacology. 178:1018-1036
Background and purpose Constipation and intestinal obstructive episodes are major health problems in cystic fibrosis (CF) patients. Three FDA-approved drugs against constipation-prone irritable bowel syndrome were tested for their ability to increase
Publikováno v:
British Journal of Pharmacology. 178:614-625
Background and purpose Medicinal cannabis is in increasing use by patients with Tourette syndrome, a neuropsychiatric disorder that affects about 1% of the general population and has a childhood onset. However, the pharmacological effects of ∆9 -te