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Autor:
Peter B. Senese, Eric Zanelli, Kristian Agmund Haanes, Joseph Kovalchin, Ad J.J.C. Bogers, Antoinette MaassenVanDenBrink, Carlos M. Villalón, Alejandro Labastida-Ramírez, Antoon J. van den Bogaerdt, Kirk W. Johnson, Laurent Meeus, Eloísa Rubio-Beltrán, Michael R Gralinski, A.H. Jan Danser
Publikováno v:
British Journal of Pharmacology
British Journal of Pharmacology, 176(24), 4681-4695. Wiley-Blackwell
British Journal of Pharmacology, 176(24), 4681-4695. Wiley-Blackwell
Background and Purpose: Triptans are 5-HT1B/1D receptor agonists (that also display 5-HT1F receptor affinity) with antimigraine action, contraindicated in patients with coronary artery disease due to their vasoconstrictor properties. Conversely, lasm
Autor:
Matteo Fornai, R Colucci, Gabrio Bassotti, Cristina Segnani, Luca Antonioli, Vincenzo Villanacci, Piero Buccianti, Corrado Blandizzi, Nunzia Bernardini, Chiara Ippolito, A Marioni, Massimo Chiarugi
Publikováno v:
British Journal of Pharmacology. 171:3728-3740
Background and Purpose The COX isoforms (COX-1, COX-2) regulate human gut motility, although their role under pathological conditions remains unclear. This study examines the effects of COX inhibitors on excitatory motility in colonic tissue from pat
Publikováno v:
British Journal of Pharmacology. 170:1221-1232
Background and Purpose The modulation of the spontaneous electrical and Ca2+ signals underlying pyeloureteric peristalsis upon nicotinic receptor activation located on primary sensory afferents (PSAs) was investigated in the mouse renal pelvis. Exper
Publikováno v:
British Journal of Pharmacology. 160:1326-1337
Background and purpose: RhoA kinase (ROCK) participates in K+ depolarization (KCl)-induced Ca2+ sensitization of contraction. Whether constitutive, depolarization- or Ca2+-activated ROCK plays the major role in this signalling system remains to be de
Publikováno v:
British Journal of Pharmacology. 158:2030-2045
Background and purpose: We investigated the cellular mechanisms underlying spontaneous contractions in the mouse renal pelvis, regulated by calcitonin gene-related peptide (CGRP). Experimental approach: Spontaneous contractions, action potentials and
Autor:
Marcello Costa, C.A. Maggi, Sandro Giuliani, Vladimir P. Zagorodnyuk, Manuela Tramontana, Simon J. H. Brookes, S Gregory
Publikováno v:
British Journal of Pharmacology. 157:607-619
Background and purpose: Bladder contractility is regulated by intrinsic myogenic mechanisms interacting with autonomic nerves. In this study, we have investigated the physiological role of spontaneous release of acetylcholine in guinea pig and rat bl
Publikováno v:
British Journal of Pharmacology. 153:1465-1473
Background and purpose: The bladder urothelium is now known to have active properties. Our aim was to investigate the contractile properties of the urinary mucosa in response to the tachykinin neurokinin A (NKA) and carbachol. Experimental approach:
Publikováno v:
British Journal of Pharmacology. 151:152-160
Background and purpose: This study analysed the contribution of the purinergic system to enteric neurotransmission in the longitudinal muscle of mouse distal colon. Experimental approach: Motor responses to exogenous ATP and to nerve stimulation in v
Publikováno v:
British Journal of Pharmacology. 150:604-612
Background and purpose: The uracil nucleotides UDP and UTP have been reported to activate P2Y2, P2Y4 and P2Y6 receptors to cause vasoconstriction. We have performed a comparative analysis of these receptors in endothelium-denuded smooth muscle from p
Publikováno v:
British Journal of Pharmacology. 148:340-349
1. To investigate the role of intracellular Ca stores in generating spontaneous excitation of the urethra, the effects of cyclopiazonic acid (CPA) on spontaneous contractions, transient increases in intracellular calcium concentration ([Ca2+]i; Ca tr