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Autor:
Aleksandar Dobric, Ivan Bernardo, Ross Vlahos, Kurt Brassington, Stanley M H Chan, Simone N. De Luca, Steven Bozinovski, Chanelle Mastronardo, Kevin Mou, Stavros Selemidis, Huei Jiunn Seow
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE Skeletal muscle dysfunction is a major comorbidity of chronic obstructive pulmonary disease (COPD). This type of muscle dysfunction may be a direct consequence of oxidative insults evoked by cigarette smoke (CS) exposure. The p
Autor:
Antonino Bongiovanni, Florent Auger, Sandrine Bergeron, Charlotte Laloux, Yaohua Chen, Camille Potey, Sophie Gautier, Régis Bordet, Aurélie Jonneaux, Clémence Leboullenger, Romain Barus, Meryem Tardivel
Publikováno v:
British Journal of Pharmacology. 178:1705-1721
BACKGROUND AND PURPOSES Cerebral microhaemorrhages (CMHs) are associated with cognitive decline in humans. In rodents, CMHs induces cognitive impairment in male mice along with sex-specific cortical and hippocampal changes affecting neural, glial and
Autor:
Ross Vlahos, Stanley M H Chan, Steven Bozinovski, Stavros Selemidis, Huei Jiunn Seow, Kurt Brassington, Aleksandar Dobric
Publikováno v:
British Journal of Pharmacology
Background and purpose It is well established that both smokers and patients with COPD are at a significantly heightened risk of cardiovascular disease (CVD), although the mechanisms underpinning the onset and progression of co-morbid CVD are largely
Autor:
Paula Bueno, Chaitanya Chakravarthi Gali, Angel Cedazo-Minguez, Ahmed Saeed, Patricia Rodriguez-Rodriguez, Anna Sandebring-Matton, Carmen M Córdoba-Beldad, Valerio Leoni, Ute Panzenboeck, Cristina Parrado-Fernandez, Ingemar Björkhem
Publikováno v:
British Journal of Pharmacology
Background and Purpose: The cerebrospinal fluid (CSF)/plasma albumin ratio (QAlb) is believed to reflect the integrity of the blood–brain barrier (BBB). Recently, we reported that QAlb is lower in females. This may be important for uptake of neurot
Autor:
Tao Wang, Ran Ma, Haixia Chen, Wenju Lu, Shiyun Liu, Chenting Zhang, Yi Li, Zizhou Zhang, Kai Yang, Yuqin Chen, Cheng Hong, Jian Wang, Xiaoyun Luo, Qian Jiang, Chunli Liu, Wenliang Guo
Publikováno v:
British Journal of Pharmacology. 178:203-216
Background and purpose Pulmonary hypertension related to pulmonary fibrosis is classed as WHO Group III, one of the most common groups which lacks effective treatment options. In this study, we aimed to uncover the underlying mechanisms, particularly
Autor:
Christina Gölz, Wieslawa Bobkiewicz, Tobias Hirnet, Michael K. E. Schäfer, Shuailong Li, Dominik Appel, Sebastian Ulbrich, Regina Hummel, Sonja Zander
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: All‐trans retinoic acid (ATRA) is a vitamin A metabolite, important in the developing and mature brain. Pre‐injury ATRA administration ameliorates ischaemic brain insults in rodents. This study examined the effects of post
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Purine metabolism in mice and human differ in terms of uricase (Uox) activity as well as hypoxanthine phosphoribosyltransferase (HPRT) activity. The aim of this study was the establishment of high HPRT activity–Uox knockout
Publikováno v:
British Journal of Pharmacology
PDE type 5 inhibitors (PDE5Is), such as sildenafil, tadalafil and vardenafil, are a class of drugs used to prolong the physiological effects of NO/cGMP signalling in tissues through the inhibition of cGMP degradation. Although these agents were origi
Publikováno v:
British Journal of Pharmacology
Background and purpose FK506 and rapamycin are modulators of FK-binding proteins (FKBP) that are used to suppress immune function after organ and hematopoietic stem cell transplantations. The drugs share the unwanted side-effect of evoking hypertensi
Autor:
Samantha Cooper, Stephen J. Hill, Jeanette Woolard, Andrea R. Sabbatini, Peter J. Scammells, Manuela Jörg, Julie E. March
Publikováno v:
British Journal of Pharmacology
Background and purpose Adenosine is a local mediator that regulates physiological and pathological processes via activation of four GPCRs (A1 , A2A , A2B , and A3 ). We have investigated the effect of two A1 -receptor-selective agonists and the novel