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Publikováno v:
British Journal of Pharmacology. 134:237-240
The effect of activation of protein kinase C (PKC) or adenylyl cyclase on release of glutamate has been investigated in a perfused slice preparation from the rat caudal trigeminal nucleus. Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) p
Publikováno v:
British Journal of Pharmacology
© 2014 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society. Background and Purpose The δ opioid receptor (DOP receptor) undergoes internalization both constitutively and i
Autor:
C J Lewis, Richard J. Evans
Publikováno v:
British Journal of Pharmacology. 131:1659-1666
Immunoreactivity for P2X(1), P2X(4) and P2X(5) receptor subtypes was detected in the smooth muscle cell layer of second and third order rat mesenteric arteries immunoreactivity, for P2X(2), P2X(3), P2X(6) and P2X(7) receptors was below the level of d
Publikováno v:
British Journal of Pharmacology. 131:655-658
The role of group III metabotropic glutamate receptors (mGluR) in ischaemic neurodegeneration is still unsettled. In order to examine a possible modulatory effect of these receptors on ischaemia-induced damage we tested the novel selective agonist (R
Autor:
Heribert Bohlen, S. A. Boehm, Cecilia Cu Zetina, G. Mathiak, Thomas Herzmann, Arnulf H. Hoelscher, Lewis F. Neville, Thomas Luebke, Guido Grass
Publikováno v:
British Journal of Pharmacology. 131:383-386
The effect of acetyl - tyrosyl-valyl-alanyl-aspartyl - chloromethylketone (ac-YVAD-cmk), an irreversible caspase-1 (IL-1beta converting enzyme, ICE) inhibitor on mortality, leukocyte and platelet counts and cytokine levels was investigated in a doubl
Autor:
Margaret R. MacLean, K Polland, Ian Morecroft, Alison Stirrat, David Alexander, Eliot H. Ohlstein, Stephen A. Douglas, Marie Gallagher
Publikováno v:
British Journal of Pharmacology. 130:201-204
Responses to human urotensin-II (hU-II) were investigated in human and rat pulmonary arteries. Rat pulmonary arteries: hU-II was a potent vasoconstrictor of main pulmonary arteries (2–3 mm i.d.) (pEC50, 8.55±0.08, n=21) and was ∼4 fold more pote
Autor:
Anthony R. Butler, A. M. Gasco, David J. Webb, Francesca A Mazzei, Roberta Fruttero, Giulia Caron, Iain R. Greig, Robert A. Field, Ian L. Megson, S Morton
Publikováno v:
British Journal of Pharmacology. 126:639-648
Previous studies show that linking acetylated glucosamine to S-nitroso-N-acetyl-D,L-penicillamine (SNAP) stabilizes the molecule and causes it to elicit unusually prolonged vasodilator effects in endothelium-denuded, isolated rat femoral arteries. He
Publikováno v:
British Journal of Pharmacology. 123:63-70
We have studied the small intestinal myoelectric response to the natural tachykinins substance P (SP), neurokinin A (NKA), neurokinin B (NKB), and the neurokinin-receptor selective agonists substance P methyl esther (SPME), [β-Ala8]neurokinin A 4-10
Publikováno v:
British Journal of Pharmacology. 123:122-128
By using the sucrose gap technique, we have investigated the effect of the metabolically stable P2Y receptor agonist, adenosine 5′-O-2-thiodiphosphate (ADPβS), on the membrane potential and tension in the circular muscle of the guinea-pig proximal
Autor:
Luis M. Orensanz, Dolores Prieto, Luis Rivera, María Victoria Barahona, Albino García-Sacristán, Medardo Hernández, Ulf Simonsen, Miguel Ángel Jiménez-Cidre
Publikováno v:
Hernández, M, Prieto, D, Orensanz, L M, Barahona, M V, Jiménez-Cidre, M, Rivera, L, García-Sacristán, A & Simonsen, U 1997, ' Involvement of a glibenclamide-sensitive mechanism in the nitrergic neurotramsmission of the pig intravesical ureter ', British Journal of Pharmacology, vol. 120, no. 4, pp. 609-616 . https://doi.org/10.1038/sj.bjp.0700952
1. The present study was designed to investigate whether potassium (K+) channels are involved in the relaxations to nitric oxide (NO) of pig intravesical ureteral preparations suspended in organ baths for isometric tension recordings. In ureteral str