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Publikováno v:
British Journal of Pharmacology. 157:1463-1473
BACKGROUND AND PURPOSE\ud \ud As adenosine 5'-triphosphate (ATP) is one of the inhibitory mediators of the bladder outflow region, this study investigates the possible release of ATP or related purines in response to electrical field stimulation (EFS
Autor:
Luis M. Orensanz, Dolores Prieto, Luis Rivera, María Victoria Barahona, Albino García-Sacristán, Medardo Hernández, Ulf Simonsen, Miguel Ángel Jiménez-Cidre
Publikováno v:
Hernández, M, Prieto, D, Orensanz, L M, Barahona, M V, Jiménez-Cidre, M, Rivera, L, García-Sacristán, A & Simonsen, U 1997, ' Involvement of a glibenclamide-sensitive mechanism in the nitrergic neurotramsmission of the pig intravesical ureter ', British Journal of Pharmacology, vol. 120, no. 4, pp. 609-616 . https://doi.org/10.1038/sj.bjp.0700952
1. The present study was designed to investigate whether potassium (K+) channels are involved in the relaxations to nitric oxide (NO) of pig intravesical ureteral preparations suspended in organ baths for isometric tension recordings. In ureteral str
Autor:
Johannes-Peter Stasch, Alexander Mülsch, Andreas Schäfer, Raimund Kast, Johann Bauersachs, Rudi Busse
Publikováno v:
British Journal of Pharmacology. 120:681-689
1. We studied the effects of 3-(5'-hydroxymethyl-2'furyl)-1-benzyl indazole (YC-1) on the activity of purified soluble guanylyl cyclase (sGC), the formation of guanosine-3':5' cyclic monophosphate (cyclic GMP) in vascular smooth muscle cells (VSMC),
Autor:
Stavros Selemidis, T.M. Cocks
Publikováno v:
British Journal of Pharmacology. 120:662-666
1. Responses to electrical field stimulation (EFS; 0.5-10 Hz, 0.2 ms duration, supramaximal voltage for 20 s) of non-adrenergic, non-cholinergic, (NANC) nerves were obtained in preparations of rat anococcygeus pre-contracted with titrated concentrati
Autor:
Emmanuel Naline, Susana Chuliá, Charles Advenier, M. Pilar D'ocon, M. Antonia Noguera, Joelle Moreau, M. Dolores Ivorra
Publikováno v:
British Journal of Pharmacology. 119:1305-1312
1. The cardiovascular activity of S-(+)-boldine, an aporphine alkaloid structurally related to papaverine, was determined. The work includes functional studies on guinea-pig isolated aorta contracted with noradrenaline, caffeine, KCl or Ca2+, and on
Autor:
Takeo Endo, Masahito Ohtsuka, Yoshiyuki Uchida, Akihiro Nomura, M. Saotome, Shizuo Hasegawa, Hiroki Ninomiya
Publikováno v:
British Journal of Pharmacology. 119:1341-1346
1. The effect of calcitonin gene-related peptide (CGRP) on airway smooth muscle is controversial. The aim of this study was to determine whether the action of CGRP on tracheal strips of guinea-pigs is modulated by epithelium and whether this peptide-
Autor:
G.L. Raymond, I.R. Wendt
Publikováno v:
British Journal of Pharmacology. 119:1029-1037
1. Simultaneous recordings of tension and [Ca2+]i were made in rat anococcygeus muscle strips to investigate possible mechanisms involved during cyclic nucleotide-mediated relaxation. Relaxation of pre-contracted muscles was induced by sodium nitropr
Publikováno v:
British Journal of Pharmacology. 119:505-510
1. In rat aortic rings contracted by phenylephrine, the relaxation induced by isoprenaline was partly inhibited by iberiotoxin, (ibTX), tetraethylammonium, 4-aminopyridine (4-AP) and 1,9-dideoxyforskolin, but not by glibenclamide. 2. In the presence
Autor:
Katsuo Kamata, Tsuneo Kobayashi
Publikováno v:
British Journal of Pharmacology. 119:583-589
1. Experiments were designed to investigate the involvement of superoxide anions in the attenuated endothelium-dependent relaxation of the rat aorta from streptozotocin (STZ)-induced diabetic rats. 2. The endothelium-dependent relaxation responses to
Publikováno v:
British Journal of Pharmacology. 119:471-478
1. In rat aortic rings precontracted with phenylephrine, the beta-adrenoceptor agonist isoprenaline (10 nM to 30 microM) produces greater relaxant effects in preparations with endothelium than in endothelium-denuded preparations. The aim of this stud