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Autor:
Aleksandar Dobric, Ivan Bernardo, Ross Vlahos, Kurt Brassington, Stanley M H Chan, Simone N. De Luca, Steven Bozinovski, Chanelle Mastronardo, Kevin Mou, Stavros Selemidis, Huei Jiunn Seow
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE Skeletal muscle dysfunction is a major comorbidity of chronic obstructive pulmonary disease (COPD). This type of muscle dysfunction may be a direct consequence of oxidative insults evoked by cigarette smoke (CS) exposure. The p
Autor:
Andrew Nelsen, Kamel Boukais, Chabha Benyahia, Lucie H. Clapp, Dan Longrois, Gulsev Ozen, Salma Mani, Xavier Norel, Adam M. Silverstein, Richard Bayles, Yves Castier, Claire Danel, Hervé Mal
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: In patients with pulmonary hypertension (PH) associated with lung disease and/or hypoxia (Group III), decreased pulmonary vascular tone and tissue hypoxia is therapeutically beneficial. PGE(2) and PGI(2) induce potent relaxati
Autor:
Paloma Narros-Fernández, Melania Guerrero-Hue, Víctor Farré-Alins, José M. Roda, Vanessa Gómez-Rangel, Juan Antonio Moreno, Juliana M. Rosa, Alfonso Rubio-Navarro, Ana I. Casas, Alejandra Palomino-Antolín, Esther Parada, Borja J. Hernández-García, Javier Egea
Publikováno v:
British Journal of Pharmacology, 176(15), 2764-2779. Wiley
Br J Pharmacol
Br J Pharmacol
Background and purpose Ischaemic stroke is a leading cause of death, disability, and a high unmet medical need. Post-reperfusion inflammation and an up-regulation of toll-like receptor 4 (TLR4), an upstream sensor of innate immunity, are associated w
Publikováno v:
British journal of pharmacology. 179(7)
Background and purpose Analogues of fibroblast growth factor 21 (FGF21) demonstrate diverse metabolic benefits in preclinical models of type 2 diabetes, dyslipidaemia, and non-alcoholic steatohepatitis (NASH), but clinical responses with different an
Publikováno v:
Br J Pharmacol
Background and purpose As an osteoclast differentiation factor, receptor activator of NF-κB ligand (RANKL) is produced by various immune cells and may be involved in the pathogenesis of osteoporosis and inflammation. Although RANKL is expressed in m
Publikováno v:
British Journal of Pharmacology. 176:282-296
BACKGROUND AND PURPOSE: Abdominal aortic aneurysm (AAA) is a degenerative disease affecting human health, but there are no safe and effective medications for AAA therapy. Cycloastragenol (CAG), derived from Astragali Radix, has various pharmacologica
Publikováno v:
British Journal of Pharmacology. 174:2302-2317
Background and Purpose Neuroinflammation is initiated by a variety of stimuli including infections, sepsis, neurodegenerative diseases or traumatic brain injury and, if not adequately controlled, can lead to various degrees of neuronal damage and beh
Autor:
Kai-Tin Hsu, Pei-Lun Hsu, Wang-Zou Tseng, Li-Wen Chen, Chia-Ling Wu, Rong-Tsun Wu, Lin-Yea Horng
Publikováno v:
British Journal of Pharmacology
Background and Purpose Memory impairment can be progressive in neurodegenerative diseases, and physiological ageing or brain injury, mitochondrial dysfunction and oxidative stress are critical components of these issues. An early clinical study has d
Publikováno v:
British Journal of Pharmacology
Background and Purpose CR4056 is a novel imidazoline-2 (I2) ligand exhibiting potent analgesic activity in animal models of pain. In this study, we investigated the effects of CR4056 in a well-established model of postoperative pain where rats develo
Autor:
Emerson Marcelo Motta, Allisson Freire Bento, Marianne N. Manjavachi, Fernanda R Malinsky, Rafael C. Dutra, Robson Costa, João Bosco Pesquero, João B. Calixto
Publikováno v:
British Journal of Pharmacology. 164:681-693
In the current study, we investigated the role of both kinin B₁ and B₂ receptors in peripheral neuropathy induced by the chronic treatment of mice with paclitaxel a widely used chemotherapeutic agent.Chemotherapy-evoked hyperalgesia was induced b