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Autor:
Aleksandar Dobric, Ivan Bernardo, Ross Vlahos, Kurt Brassington, Stanley M H Chan, Simone N. De Luca, Steven Bozinovski, Chanelle Mastronardo, Kevin Mou, Stavros Selemidis, Huei Jiunn Seow
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE Skeletal muscle dysfunction is a major comorbidity of chronic obstructive pulmonary disease (COPD). This type of muscle dysfunction may be a direct consequence of oxidative insults evoked by cigarette smoke (CS) exposure. The p
Publikováno v:
British journal of pharmacology. 179(7)
Background and purpose Analogues of fibroblast growth factor 21 (FGF21) demonstrate diverse metabolic benefits in preclinical models of type 2 diabetes, dyslipidaemia, and non-alcoholic steatohepatitis (NASH), but clinical responses with different an
Autor:
Kai-Tin Hsu, Pei-Lun Hsu, Wang-Zou Tseng, Li-Wen Chen, Chia-Ling Wu, Rong-Tsun Wu, Lin-Yea Horng
Publikováno v:
British Journal of Pharmacology
Background and Purpose Memory impairment can be progressive in neurodegenerative diseases, and physiological ageing or brain injury, mitochondrial dysfunction and oxidative stress are critical components of these issues. An early clinical study has d
Autor:
Sotiria Bexis, James R. Docherty
Publikováno v:
British Journal of Pharmacology. 158:259-266
Background and purpose: We have investigated the ability of the β3-adrenoceptor antagonist 1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4,-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride (SR59230A) to affect the hyperthermia produced by methylen
Autor:
Reinis Vilskersts, Solveiga Grinberga, Liga Zvejniece, Ivars Kalvinsh, Baiba Svalbe, Elina Skapare, Janis Kuka, Helena Cirule, Edgars Liepinsh, Maija Dambrova
Publikováno v:
British Journal of Pharmacology. 157:1549-1556
Mildronate [3-(2,2,2-trimethylhydrazinium) propionate] is an anti-ischaemic drug whose mechanism of action is based on its inhibition of L-carnitine biosynthesis and uptake. As L-carnitine plays a pivotal role in the balanced metabolism of fatty acid
Autor:
Jui-In Kai, Yi Wang, Cheng Chieh Tsai, Yu Tzu Chang, Wei-Ching Huang, Chi Yun Wang, Chia Ling Chen, Chiou Feng Lin
Publikováno v:
British Journal of Pharmacology. 157:1004-1013
Background and purpose: Excessive inflammation and apoptosis are pathological features of endotoxaemic acute renal failure. Activation of glycogen synthase kinase-3 (GSK-3) is involved in inflammation and apoptosis. We investigated the effects of inh
Publikováno v:
British Journal of Pharmacology. 157:994-1003
Background and purpose: Renal function can be assessed by measuring albuminuria and glomerular filtration rate, and the latter is often estimated by creatinine clearance rate (Ccr). Transforming growth factor-β1 (TGF-β1) and vascular endothelial gr
Publikováno v:
British Journal of Pharmacology. 148:233-244
After partial nerve injury, the central analgesic effect of systemically administered gabapentin is mediated by both supraspinal and spinal actions. We further evaluate the mechanisms related to the supraspinally mediated analgesic actions of gabapen
Autor:
Heribert Bohlen, S. A. Boehm, Cecilia Cu Zetina, G. Mathiak, Thomas Herzmann, Arnulf H. Hoelscher, Lewis F. Neville, Thomas Luebke, Guido Grass
Publikováno v:
British Journal of Pharmacology. 131:383-386
The effect of acetyl - tyrosyl-valyl-alanyl-aspartyl - chloromethylketone (ac-YVAD-cmk), an irreversible caspase-1 (IL-1beta converting enzyme, ICE) inhibitor on mortality, leukocyte and platelet counts and cytokine levels was investigated in a doubl
Autor:
Margaret R. MacLean, K Polland, Ian Morecroft, Alison Stirrat, David Alexander, Eliot H. Ohlstein, Stephen A. Douglas, Marie Gallagher
Publikováno v:
British Journal of Pharmacology. 130:201-204
Responses to human urotensin-II (hU-II) were investigated in human and rat pulmonary arteries. Rat pulmonary arteries: hU-II was a potent vasoconstrictor of main pulmonary arteries (2–3 mm i.d.) (pEC50, 8.55±0.08, n=21) and was ∼4 fold more pote