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Publikováno v:
British Journal of Pharmacology. 179:1338-1352
BACKGROUND AND PURPOSE Prostacyclin mimetics express potent vsoactive effects via prostanoid receptors which are not defined unequivocally, as to date no study has considered sex as a factor. The aim of this study was to determine the contribution of
Regulation of I Ca,L and force by PDEs in human‐induced pluripotent stem cell‐derived cardiomyocytes
Autor:
Ingra Mannhardt, Hans O. Pinnschmidt, Arne Hansen, Torsten Christ, Djemail Ismaili, Umber Saleem, Thomas Eschenhagen, Thomas G. Schulze
Publikováno v:
British Journal of Pharmacology. 177:3036-3045
Background and purpose Phosphodiesterases (PDEs) are important regulators of β-adrenoceptor signalling in the heart. While PDE4 is the most important isoform that regulates ICa,L and force in rodent cardiomyocytes, the dominant isoform in adult huma
Autor:
Marek Toczek, Irena Kasacka, Marta Baranowska-Kuczko, Anna Pędzińska-Betiuk, Ewa Harasim-Symbor, Barbara Malinowska, Jolanta Weresa
Publikováno v:
British Journal of Pharmacology. 174:2114-2129
Background and Purpose Fatty acid amide hydrolase (FAAH) inhibitors are postulated to possess anti-hypertensive potential, because their acute injection decreases BP in spontaneously hypertensive rats (SHR), partly through normalization of cardiac co
Autor:
Tor Skomedal, Ata Sh, Christen P. Dahl, Jon Riise, Geir Øystein Andersen, Øivind Ørstavik, Eirik Qvigstad, Jan-Bjørn Osnes, Finn Olav Levy
Publikováno v:
British Journal of Pharmacology. 171:5169-5181
Background and Purpose Levosimendan is known as a calcium sensitizer, although it is also known to inhibit PDE3. We aimed to isolate each component and estimate their contribution to the increased cardiac contractility induced by levosimendan. Experi
Autor:
Tor Skomedal, Cam H.T. Nguyen, Silja Meier, Geir Christensen, Ivar Sjaastad, Øivind Ørstavik, Karina Hougen, J.-B. Osnes, Eirik Qvigstad, Lise Román Moltzau, Jan Magnus Aronsen, Finn Olav Levy
Publikováno v:
British Journal of Pharmacology. 170:366-379
Background and Purposes Myocardial C-type natriuretic peptide (CNP) levels are increased in heart failure. CNP can induce negative inotropic (NIR) and positive lusitropic responses (LR) in normal hearts, but its effects in failing hearts are not know
Autor:
Miguel Pérez-Aso, M.A. Noguera, Francesc Jiménez-Altayó, Vanessa Segura, S Estrada, Ivorra, Elisabet Vila, Pilar D'Ocon, JF Seller, Nicla Flacco
Publikováno v:
British Journal of Pharmacology. 169:413-425
Background and Purpose To analyse the relative contribution of β1-, β2- and β3-adrenoceptors (Adrb) to vasodilatation in conductance and resistance vessels, assessing the role of cAMP and/or NO/cGMP signalling pathways. Experimental Approach Rat m
Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy
Autor:
Mandy M Y Tse, Beshay N M Zordoky, Bruce D. Hammock, Hassan N. Althurwi, Ghada Abdelhamid, Ayman O.S. El-Kadi
Publikováno v:
British Journal of Pharmacology. 168:1794-1807
Background and Purpose We have previously shown that isoprenaline-induced cardiac hypertrophy causes significant changes in the expression of cytochromes P450 (CYP) and soluble epoxide hydrolase (sEH) genes. Therefore, it is important to examine whet
Publikováno v:
British Journal of Pharmacology. 166:721-736
BACKGROUND AND PURPOSE β-Adrenoceptors are expressed in human and experimental animal breast cancer cells. However, the effect of the agonists and antagonists reported on cell proliferation and tumour growth was paradoxical, precluding their utiliza
Publikováno v:
British Journal of Pharmacology. 165:274-288
BACKGROUND AND PURPOSE Interactions between protein phosphatase inhibition and matrix metalloproteinase (MMP)-9 expression have implications for tissue remodelling after injury. Stimulation of β-adrenoceptors could affect such interactions as isopre
Autor:
József András Szentmiklósi, Gábor Harmati, Norbert Szentandrássy, Péter P. Nánási, Gábor Szénási, László Bárándi, Gábor Szabó, Tamás Bányász, Balázs Horváth, János Magyar
Publikováno v:
British Journal of Pharmacology. 162:890-896
BACKGROUND AND PURPOSE While the slow delayed rectifier K+ current (IKs) is known to be enhanced by the stimulation of β-adrenoceptors in several mammalian species, phosphorylation-dependent regulation of the rapid delayed rectifier K+ current (IKr)