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Publikováno v:
British Journal of Pharmacology, 117(3), 419-426. Wiley-Blackwell
1 The effects of increased cellular cyclic AMP levels induced by isoprenaline, forskolin and 8-bromo-adenosine 3':5'-cyclic monophosphate (8-Br-cyclic AMP) on phosphoinositide metabolism and changes in intracellular Ca2+ elicited by methacholine and
Publikováno v:
British Journal of Pharmacology. 117:258-267
1. The effects of 2,5 di-(tert-butyl)-1,4-benzohydroquinone (TBQ), a putative inhibitor of the sarcoplasmic reticulum (SR) Ca2+ pump, on twitch tension, time course and SR Ca2+ content have been studied at different stimulation frequencies (0.5-3 Hz)
Autor:
Esteban J. Morcillo, Benjamín Sarriá, Charles Advenier, Joelle Moreau, Emmanuel Naline, Julio Cortijo, José M. Cerdá
Publikováno v:
British Journal of Pharmacology. 116:2569-2574
1. Human isolated bronchi have been investigated as fresh tissue or after storage (7 and 30 days) at -196 degrees C in foetal calf serum containing 1.8 M dimethyl sulphoxide. 2. After cryopreservation, the maximal contractile response to acetylcholin
Publikováno v:
British Journal of Pharmacology. 115:158-162
1. Inhibitory non-adrenergic, non-cholinergic (NANC) responses were studied in isolated strips from the rabbit internal anal sphincter. 2. In the presence of atropine and guanethidine, transmural field stimulation induced frequency-dependent relaxati
Autor:
R. Jones, Yueming Qian
Publikováno v:
British Journal of Pharmacology. 115:163-171
1. The possibility that prostacyclin (IP-) receptor agonists inhibit spontaneous contractions of the rat isolated colon by activating enteric neurones has been investigated. Cicaprost was used as the test agonist because of its high stability, select
Autor:
John R. Fozard, Roger C. Small, K. Archer, Andrew J. Miller, A. Martin, K.H. Buchheit, Keith R.F. Elliott, S.J. Cook, T. Müller, R.W. Foster
Publikováno v:
British Journal of Pharmacology. 114:143-151
1. SCA40 (1nM-10 microM), isoprenaline (1-300 nM) and levcromakalim (100 nM-10 microM) each produced concentration-dependent suppression of the spontaneous tone of guinea-pig isolated trachea. Propranolol (1 microM) markedly (approximately 150 fold)
Autor:
Andrew P. Stork, Thomas M. Cocks
Publikováno v:
British Journal of Pharmacology. 113:1099-1104
1. Human epicardial coronary artery rings, freshly obtained from cardiac transplant patients, were examined for their responses to endothelium-derived relaxing factor (EDRF)-releasing agents. 2. Functional antagonism profoundly influenced relaxation
Autor:
Mabayoje A. Oriowo
Publikováno v:
British Journal of Pharmacology. 113:699-702
1. The possible existence of atypical beta-adrenoceptors in vascular smooth muscle of the rat common carotid artery was examined in this study. 2. Isoprenaline produced concentration-dependent relaxation of noradrenaline (10(-7) M) precontracted ring
Publikováno v:
British Journal of Pharmacology. 113:1043-1049
1. The pharmacological actions of the beta-adrenoceptor antagonists, celiprolol, bisoprolol and propranolol were investigated in human lung tissue by radioligand binding experiments as well as in human isolated bronchi by functional experiments in or
Publikováno v:
British Journal of Pharmacology. 113:143-150
1. Experiments were carried out to characterize pharmacologically the 5-hydroxytryptamine (5-HT) receptor types which mediate inhibition of spontaneous contractions of the intertaenial circular muscle in human isolated colon. 2. 5-HT caused a reprodu